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Full-Text Articles in Medicine and Health Sciences
Imaging Submillisecond Membrane Potential Changes From Individual Regions Of Single Axons, Dendrites And Spines, Srdjan D. Antic
Imaging Submillisecond Membrane Potential Changes From Individual Regions Of Single Axons, Dendrites And Spines, Srdjan D. Antic
UCHC Articles - Research
A central question in neuronal network analysis is how the interaction between individual neurons produces behavior and behavioral modifications. This task depends critically on how exactly signals are integrated by individual nerve cells functioning as complex operational units. Regional electrical properties of branching neuronal processes which determine the input-output function of any neuron are extraordinarily complex, dynamic, and, in the general case, impossible to predict in the absence of detailed measurements. To obtain such a measurement one would, ideally, like to be able to monitor, at multiple sites, subthreshold events as they travel from the sites of origin (synaptic contacts …
A Strict Correlation Between Dendritic And Somatic Plateau Depolarizations In The Rat Prefrontal Cortex Pyramidal Neurons, Srdjan D. Antic
A Strict Correlation Between Dendritic And Somatic Plateau Depolarizations In The Rat Prefrontal Cortex Pyramidal Neurons, Srdjan D. Antic
UCHC Articles - Research
One of the fundamental problems in neurobiology is to understand the cellular mechanism for sustained neuronal activity (neuronal UP states). Prefrontal pyramidal neurons readily switch to a long-lasting depolarized state after suprathreshold stimulation of basal dendrites. Analysis of the dendritic input–output function revealed that basal dendrites operate in a somewhat binary regimen (DOWN or UP) in regard to the amplitude of the glutamate-evoked electrical signal. Although the amplitude of the dendritic potential quickly becomes saturated (dendritic UP state), basal dendrites preserve their ability to code additional increase in glutamatergic input. Namely, after the saturation of the plateau amplitude, an additional …