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Full-Text Articles in Medicine and Health Sciences
The Transcriptomics To Proteomics Of Hair Cell Regeneration: Looking For A Hair Cell In A Haystack, Gopinath Rajadinakaran
The Transcriptomics To Proteomics Of Hair Cell Regeneration: Looking For A Hair Cell In A Haystack, Gopinath Rajadinakaran
UCHC Articles - Research
Mature mammals exhibit very limited capacity for regeneration of auditory hair cells, while all non-mammalian vertebrates examined can regenerate them. In an effort to find therapeutic targets for deafness and balance disorders, scientists have examined gene expression patterns in auditory tissues under different developmental and experimental conditions. Microarray technology has allowed the large-scale study of gene expression profiles (transcriptomics) at whole-genome levels, but since mRNA expression does not necessarily correlate with protein expression, other methods, such as microRNA analysis and proteomics, are needed to better understand the process of hair cell regeneration. These technologies and some of the results of …
The Decade Of The Dendritic Nmda Spike, Srdjan D. Antic, Wen-Liang Zho, Anna R. Moore, Shaina M. Shor, Katerina D. Ikonomu
The Decade Of The Dendritic Nmda Spike, Srdjan D. Antic, Wen-Liang Zho, Anna R. Moore, Shaina M. Shor, Katerina D. Ikonomu
UCHC Articles - Research
In the field of cortical cellular physiology, much effort has been invested in understanding thick apical drites of pyramidal neurons and the regenerative sodium and calcium spikes that take place in the apical trunk. Here we focus on thin dendrites of pyramidal cells (basal, oblique, and tuft dendrites), and we discuss one relatively novel form of an electrical signal (“NMDA spike”) that is specific for these branches. Basal, oblique, and apical tuft dendrites receive a high density of glutamatergic synaptic contacts. Synchronous activation of 10–50 neighboring glutamatergic synapses triggers a local dendritic regenerative potential, NMDA spike/plateau, which is characterized by …