Tnf And Cd28 Signaling Play Unique But Complementary Roles In The Systemic Recruitment Of Innate Immune Cells After Staphylococcus Aureus Enterotoxin A Inhalation, Julia Svedova, Naomi Tsurutani, Wenhai Liu, Kamal M. Khanna, Anthony T. Vella

UCHC Articles - Research

TNF and CD28 Signaling Play Unique but Complementary Roles in the Systemic Recruitment of Innate Immune Cells after Staphylococcus aureus Enterotoxin A Inhalation.

Cyclin-Dependent Kinase Crk9, Required For Spliced Leader Trans Splicing Of Pre-Mrna In Trypanosomes, Functions In A Complex With A New L-Type Cyclin And A Kinetoplastid-Specific Protein., Nitika Badjatia, Sung Hee Park, Daniela L. Ambrósio, Justin K. Kirkham, Arthur Günzl

UCHC Articles - Research

In eukaryotes, cyclin-dependent kinases (CDKs) control the cell cycle and critical steps in gene expression. The lethal parasite Trypanosoma brucei, member of the phylogenetic order Kinetoplastida, possesses eleven CDKs which, due to high sequence divergence, were generically termed CDC2-related kinases (CRKs). While several CRKs have been implied in the cell cycle, CRK9 was the first trypanosome CDK shown to control the unusual mode of gene expression found in kinetoplastids. In these organisms, protein-coding genes are arranged in tandem arrays which are transcribed polycistronically. Individual mRNAs are processed from precursor RNA by spliced leader (SL) trans splicing and polyadenylation. CRK9 …

Dnah6 And Its Interactions With Pcd Genes In Heterotaxy And Primary Ciliary Dyskinesia, Stephen M. King

UCHC Articles - Research

Heterotaxy, a birth defect involving left-right patterning defects, and primary ciliary dyskinesia (PCD), a sinopulmonary disease with dyskinetic/immotile cilia in the airway are seemingly disparate diseases. However, they have an overlapping genetic etiology involving mutations in cilia genes, a reflection of the common requirement for motile cilia in left-right patterning and airway clearance. While PCD is a monogenic recessive disorder, heterotaxy has a more complex, largely non-monogenic etiology. In this study, we show mutations in the novel dynein gene DNAH6 can cause heterotaxy and ciliary dysfunction similar to PCD. We provide the first evidence that trans-heterozygous interactions between DNAH6 and …