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Full-Text Articles in Medicine and Health Sciences
Anatomical And Behavioral Investigation Of C1ql3 In The Mouse Suprachiasmatic Nucleus, David C. Martinelli
Anatomical And Behavioral Investigation Of C1ql3 In The Mouse Suprachiasmatic Nucleus, David C. Martinelli
UCHC Articles - Research
Many biochemical, physiological, and behavioral processes such as glucose metabolism, body temperature, and sleep-wake cycles show regular daily rhythms. These circadian rhythms are adjusted to the environmental light-dark cycle by a central pacemaker located in the suprachiasmatic nucleus (SCN) in order for the processes to occur at appropriate times of day. Here, we investigated the expression and function of a synaptic organizing protein, C1QL3, in the SCN. We found that C1ql3 is robustly expressed in the SCN. C1ql3 knockout mice have a reduced density of excitatory synapses in the SCN. In addition, these mice exhibited less consolidated activity to the …
Psma Redirects Cell Survival Signaling From The Mapk To The Pi3k-Akt Pathways To Promote The Progression Of Prostate Cancer, Leslie Ann Caromile, Kristina Dortche, M. Mamunur Rahman, Christina L. Grant, Christopher Stoddard, Linda H. Shapiro
Psma Redirects Cell Survival Signaling From The Mapk To The Pi3k-Akt Pathways To Promote The Progression Of Prostate Cancer, Leslie Ann Caromile, Kristina Dortche, M. Mamunur Rahman, Christina L. Grant, Christopher Stoddard, Linda H. Shapiro
UCHC Articles - Research
Increased abundance of the prostate-specific membrane antigen (PSMA) on prostate epithelium is a hallmark of advanced metastatic prostate cancer (PCa) and correlates negatively with prognosis. However, direct evidence that PSMA functionally contributes to PCa progression remains elusive. We generated mice bearing PSMA-positive or PSMA-negative PCa by crossing PSMA-deficient mice with transgenic PCa (TRAMP) models, enabling direct assessment of PCa incidence and progression in the presence or absence of PSMA. Compared with PSMA-positive tumors, PSMA-negative tumors were smaller, lower-grade, and more apoptotic with fewer blood vessels, consistent with the recognized proangiogenic function of PSMA. Relative to PSMA-positive tumors, tumors lacking PSMA …