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Full-Text Articles in Medicine and Health Sciences
A Strict Correlation Between Dendritic And Somatic Plateau Depolarizations In The Rat Prefrontal Cortex Pyramidal Neurons, Srdjan D. Antic
A Strict Correlation Between Dendritic And Somatic Plateau Depolarizations In The Rat Prefrontal Cortex Pyramidal Neurons, Srdjan D. Antic
UCHC Articles - Research
One of the fundamental problems in neurobiology is to understand the cellular mechanism for sustained neuronal activity (neuronal UP states). Prefrontal pyramidal neurons readily switch to a long-lasting depolarized state after suprathreshold stimulation of basal dendrites. Analysis of the dendritic input–output function revealed that basal dendrites operate in a somewhat binary regimen (DOWN or UP) in regard to the amplitude of the glutamate-evoked electrical signal. Although the amplitude of the dendritic potential quickly becomes saturated (dendritic UP state), basal dendrites preserve their ability to code additional increase in glutamatergic input. Namely, after the saturation of the plateau amplitude, an additional …