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Loma Linda University Electronic Theses, Dissertations & Projects
Fetal Intrauterine Growth Restriction; Uterine Vascular Adaptation; Basal Uterine Vascular Tone;
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Expression And Function Of Ca2+-Activated K+ Channels In Uterine Arteries, Ronghui Zhu
Expression And Function Of Ca2+-Activated K+ Channels In Uterine Arteries, Ronghui Zhu
Loma Linda University Electronic Theses, Dissertations & Projects
Chronic hypoxia during pregnancy is one of the most common insults to the maternal cardiovascular system and fetal development, and is associated with increased uterine vascular tone and heightened risk of preeclampsia and fetal intrauterine growth restriction (IUGR). The present study tested the hypothesis that calcium-activated potassium (KCa) channels play an essential role in uterine vascular adaptation to pregnancy, which is inhibited by chronic hypoxia during gestation. Uterine arteries (UAs) were isolated from nonpregnant ewes (NPUAs) and near-term pregnant ewes (PUAs) that had been maintained at sea level (~300 m) or exposed to high altitude (3,801 m) for 110 days. …