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Full-Text Articles in Medicine and Health Sciences
Immunization By Radiotherapy: Enhancing An Immune-Mediated Abscopal Effect, Amy Steffen
Immunization By Radiotherapy: Enhancing An Immune-Mediated Abscopal Effect, Amy Steffen
Biology and Microbiology Graduate Students Plan B Research Projects
Radiotherapy aims to destroy tumors by inducing DNA damage in their cells at the local irradiation site. Its immune-mediated systemic effects, called abscopal effect, has shown to enhance anti-tumor immunity when combined with immune therapies and thus, have gained attention by researchers and clinicians to investigate. Below is a summary of the fundamentals of cancer and the immune system’s response to it, as well as the changes in the phenotype and microenvironment of tumor cells after exposure to radiation. Impacts of the abscopal effect and the induction of effective antitumor immunity with various immune therapy strategies will be outlined. The …
Increasing The Clinical Efficacy Of Radiotherapeutics For Solid Tumors By Inhibition Of Hypoxia Inducible Factor-1a, Austin Levi Walz
Increasing The Clinical Efficacy Of Radiotherapeutics For Solid Tumors By Inhibition Of Hypoxia Inducible Factor-1a, Austin Levi Walz
Biology and Microbiology Graduate Students Plan B Research Projects
Radiotherapy is commonly used in a variety of tumor types and is effective in control of long term progression and may be curative under certain circumstances. Radiotherapeutics have been shown to be the single most effective therapeutic for cancer and only account for 5% of the total cost. However, treatment of cells with radiation causes the tumor microenvironment to undergo changes and leads to cycles of hypoxia inside the tumor which allows for the cell to undergo angiogenesis, metastasize and may lead to repopulation of the tumor. Current systemic chemotherapeutics typically have an additive toxicity due to the unintended targeting …
A Biological Review Of Mental Illness: An Overview Of Genetics And Pathophysiology Of Schizophrenia, Major Depression, And Addiction, Christopher R. Angerhofer
A Biological Review Of Mental Illness: An Overview Of Genetics And Pathophysiology Of Schizophrenia, Major Depression, And Addiction, Christopher R. Angerhofer
Biology and Microbiology Graduate Students Plan B Research Projects
Novel approaches in understanding mental illness present solutions to current issues in treatment and diagnosis. With advancements in genetics and neurology, the etiology and pathophysiology of mental illness is slowly unwrapping. In discovering biomarkers for depression, addiction, and schizophrenia, the precision for preventing, diagnosing, and treating these disorders increases. The aim of this paper is to review current research for addiction, major depression, and schizophrenia in genetics and physiology, while also clarifying the need for reclassifying mental illness as diseases with a pathophysiological basis, not syndromal, idiopathic disorders. Mental illness is dynamic in that it encompasses both environmental and biological …
Transcranial Magnetic Stimulaton: In-Depth Review Of Methods, Efficacy And Future Applications, Matthew Carpenter
Transcranial Magnetic Stimulaton: In-Depth Review Of Methods, Efficacy And Future Applications, Matthew Carpenter
Biology and Microbiology Graduate Students Plan B Research Projects
Transcranial magnetic stimulation (TMS) has been regarded as a novel technique of neuromodulation with applications that span from the treatment of depression or depression related symptoms to the mapping of cerebral regions. This review takes an in depth look into the different forms of magnetic stimulation including repetitive TMS, theta-burst stimulation, and navigated TMS. The efficacy of these different forms of stimulation is addressed as well as comparisons made to current standards being used. Potential clinically relevant future applications of TMS are also discussed from the treatment of obsessive compulsive disorder to improving motor function after stroke. The purpose of …
Mild Traumatic Brain Injuries And Cte: A Review Highlighting The Connection Between The Two, Leandre Kennedy
Mild Traumatic Brain Injuries And Cte: A Review Highlighting The Connection Between The Two, Leandre Kennedy
Biology and Microbiology Graduate Students Plan B Research Projects
Chronic Traumatic Encephalopathy (CTE) is a traumatic brain injury based disease that is garnering a lot of attention in the United States. The purpose of this paper is to conduct an extensive review of the information available about the condition. Recently there has been a limited amount of published information and treatment opportunities are rare since the only way of diagnosing has come post mortem. Various literary reviews and experiments were analyzed for appropriate information regarding CTE’s pathology and treatments and only peer reviewed published works were allowed in this paper. This resulted in promising information about the disease and …