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Articles 1 - 9 of 9
Full-Text Articles in Medicine and Health Sciences
Novel Application Of Graphene Oxide Based-Biosensor Utilizing Crispr/Dcas9 For Rapid Detection Of Antibiotic Resistance Genes, Joel Omage
Masters Theses & Specialist Projects
Antibiotic resistance is one of the biggest public health challenges globally. To combat this threat, we have designed a method for the facile and rapid detection of antibiotic resistance gene (ARG) in bacteria. We utilized an emerging tool termed the clusters of regularly interspaced short palindromic repeats (CRISPR) in complex with deactivated CRISPR associated proteins (dCas9) on conjugated 2-dimensional graphene oxide (GO) sheets. Nuclease-deactivated Cas9 in complex with customized single guided RNA (sgRNA) was used for the target DNA recognition. The sgRNA was easy to design and we demonstrated that it is complementary to its target sequence by performing a …
Validation Of A Novel Vo2max Protocol, Griffin Green
Validation Of A Novel Vo2max Protocol, Griffin Green
Masters Theses & Specialist Projects
Though there are several to choose from, the Bruce protocol is the most commonly utilized treadmill protocol when assessing maximal oxygen consumption (VO2max). Originally developed for cardiac patients, the Bruce protocol may not be an appropriate treadmill protocol for young or trained individuals with higher levels of cardiorespiratory fitness. The steep grade used often leads localized muscular fatigue, which may cause participants to end the test prior to reaching their true VO2max. Another popular protocol, the Astrand, also utilizes a steep grade, but the speed remains constant. Similar to the Bruce, the Astrand protocol may not prompt a maximal cardiovascular …
Effects Of Bingocize® On Overall Physical Activity, Functional Performance, Blood Glucose Level, Sleep Quantity, And Quality Among Older Adults In Assisted-Living Facilities, Sepehr Rassi
Masters Theses & Specialist Projects
Bingocize® has been established as an effective falls prevention exercise program for older adults, but its effects on older adults residing in assisted-living facilities have not been examined. The purpose of this investigation was to assess the effects of Bingocize® on overall physical activity level, functional performance, blood glucose level, sleep quantity and quality in older adults who live in assisted-living facilities. Participants (N = 13; mean age 86.23 ± 3.90) were asked to participate in Bingocize® while wearing activity trackers (Fitbit Charge 3 HR) for 10 weeks. The activity trackers were used to assess the average number of steps …
Reliability And Validity Of An Assessment Of Engagement In Nursing Home Residents During Bingocize®, Elizabeth Batson Apelt
Reliability And Validity Of An Assessment Of Engagement In Nursing Home Residents During Bingocize®, Elizabeth Batson Apelt
Masters Theses & Specialist Projects
Research suggests nursing home residents are often socially isolated and physically inactive despite overwhelming evidence that both social engagement and physical activity are crucial for healthy aging (Jones, Sung, & Moyle, 2018; Yen & Lin, 2018; Ice, 2002; Jansson et al., 2017). Bingocize® is a program that combines exercise and the game of Bingo to improve the quality of life, physical health, and social engagement of certified nursing facility (CNF) residents. The purpose of this study is to determine the level of social engagement displayed by CNF residents during Bingocize® using the Fun and Social Engagement Evaluation (FUSE). Reliability and …
Assessing Biomass Fuel Consumption In Kasigau, Kenya As A Predictor Of Hypertension, Conner Hounshell
Assessing Biomass Fuel Consumption In Kasigau, Kenya As A Predictor Of Hypertension, Conner Hounshell
Mahurin Honors College Capstone Experience/Thesis Projects
Cardiovascular disease is the leading cause of death globally and disproportionately affects low- and middle-income countries, such as Kenya. Hypertension is the leading risk factor for cardiovascular disease and is influenced by a variety of factors such as diet, tobacco use, and genetics. One such factor linked to hypertension is exposure to air pollution, but minimal research exists on the effects of household air pollution. Hypertension that is not related to common Western risk indicators, such as waist-to-hip ratio, body mass indices, and hypercholestorlemia, is prevalent in the community of Kasigau, Kenya, along with the prevalence of risks for household …
Impact Of Geographic Location And Social Determinants Of Health On Lung Cancer Incidence And Mortality Rates, Katherine Ashley
Impact Of Geographic Location And Social Determinants Of Health On Lung Cancer Incidence And Mortality Rates, Katherine Ashley
Mahurin Honors College Capstone Experience/Thesis Projects
This paper studies the effect of geographic location and socioeconomic status, specifically level of education and income, on rates of incidence and mortality of lung and bronchus cancer. While some prior studies have focused on socioeconomic status’ and global geographic location’s impact on these rates, few have focused on the impact in Appalachian Kentucky and non-Appalachian Kentucky. In this paper, level of education and income are controlled for using four variables: median household income, percentage of persons in poverty, percentage of high school graduates or higher who are at least 25, and percentage of persons with a bachelor’s degree or …
A Look At Gene Control: Tracking The Ccnd1 Gene, Bryan Anders
A Look At Gene Control: Tracking The Ccnd1 Gene, Bryan Anders
Mahurin Honors College Capstone Experience/Thesis Projects
Cancer occurs when the cell does not properly control its own cell cycle. It then replicates in an out of control fashion leading to the death of various organs and then the demise of the organism as a whole. As it seems to have always been a problem for cell-based life, certain safeguards against cancer have been evolved over time. One such method comes in the form of prevention via cyclin proteins, which are encoded from cyclin genes. The gene that is the focus of this research is the CCND1, or cyclin D1, gene that controls the progression through various …
The Impact Of Exercise In Spaceflight And Microgravity Environments, William Bybee
The Impact Of Exercise In Spaceflight And Microgravity Environments, William Bybee
Mahurin Honors College Capstone Experience/Thesis Projects
Since mankind’s first spaceflight, a significant barricade in reaching distant planets has been the damaging effects of microgravity upon the human body. Effects range from loss in bone mineral density and severe muscle atrophy to autoimmune disorders. The most effective countermeasure of these effects to date is exercise. Implementation of exercise in microgravity is not an easy task, so various specialized equipment must be utilized to effectively administer it. Even with this equipment, exercise as it is currently used does not entirely prevent body systems from undergoing detrimental changes. New modalities and implementations are currently being investigated that may significantly …
The Role Of Mitochondrial Pyruvate Carrier 1 (Mpc1) In Heart Failure And Its Implications For Cardiac Recovery, Obadiah Issachar Kirk
The Role Of Mitochondrial Pyruvate Carrier 1 (Mpc1) In Heart Failure And Its Implications For Cardiac Recovery, Obadiah Issachar Kirk
Mahurin Honors College Capstone Experience/Thesis Projects
Heart failure (HF) is a complex syndrome with high mortality rates around the world. HF also has diverse etiology as many things contribute such as hypertension, obesity, coronary artery disease, inflammation, and cardiac arrhythmias. Studies have shown that unloading of a failing heart with a left ventricular assist device (LVAD) can lead to cardiac recovery in a subpopulation of individuals with advanced HF. RNA-sequencing and protein expression analysis of myocardial tissue from HF patients who underwent the LVAD implant and heart transplant indicated that subpopulation of HF patients who responded to LVAD unloading had significantly lower levels of mitochondrial pyruvate …