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Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Leaving Ligand Effects On Reactivity And Solubility Of Monofunctional Platinum(Ii) Anticancer Complexes, Heidi Linn Hruska Millay
Leaving Ligand Effects On Reactivity And Solubility Of Monofunctional Platinum(Ii) Anticancer Complexes, Heidi Linn Hruska Millay
Masters Theses & Specialist Projects
Monofunctional platinum(II) complexes, such as phenanthriplatin and pyriplatin, have notably different characteristics from the bifunctional anticancer complexes, such as cisplatin and oxaliplatin, which have detrimental toxicities and resistance associated with them. The unique properties of the monofunctional complexes may be exploited to target cancer cells without producing the toxic side effects associated with the current FDA-approved platinum-based anticancer drugs. To advance the understanding of these monofunctional platinum(II) complexes, this study replaced the chloride leaving ligand with an acetate group, which should increase solubility and alter the rate of reactivity with key amino acid and nucleotide targets. Phenanthriplatin and pyriplatin compounds …
Steenbergen, Joel (Fa 1325), Manuscripts & Folklife Archives
Steenbergen, Joel (Fa 1325), Manuscripts & Folklife Archives
FA Finding Aids
Finding aid and full-text scan of paper (Click on “Additional Files” below) for Folklife Archives Project 1325. Student folk studies project titled “Ginseng: The Wonder of the World,” about the history and folklore of ginseng in the United States, its uses, the harvesting process and tools.
Effects Of Ef-24 And Cisplatin On Cancer, Renal, And Auditory Cells, Denis Hodzic
Effects Of Ef-24 And Cisplatin On Cancer, Renal, And Auditory Cells, Denis Hodzic
Masters Theses & Specialist Projects
Cisplatin is a chemotherapy drug effective against several forms of cancer, but can also cause serious side-effects, including nephrotoxicity and ototoxicity. Curcumin, a natural plant compound, can increase cisplatin’s anti-cancer activity and counteract cisplatin’s deleterious effect on the auditory and renal systems. Unfortunately, curcumin exhibits poor bioavailability, which has promoted interest in the development of synthetic curcumin analogs (curcuminoids) that are soluble, target cancer, and do not cause side effects. This study investigated whether the curcuminoid (3E,5E)-3,5-bis[(2-fluorophenyl) methylene]-4-piperidinone (EF-24) increases the anti-cancer effects of cisplatin against a human ovarian cancer cell line (A2780) and its cisplatin-resistant counterpart (A2780cis), while preventing …
Observation And Self-Report Of Fun And Social Engagement Of Nursing Home Residents During Bingocize®, Lauren Rene Stevens
Observation And Self-Report Of Fun And Social Engagement Of Nursing Home Residents During Bingocize®, Lauren Rene Stevens
Masters Theses & Specialist Projects
Individuals in certified nursing facilities (CNF) often experience social isolation and have limited opportunities to exercise. Bingocize®, an evidence-based healthpromotion program, is a combination of exercise and Bingo and provides opportunities for CNF resident interaction. Limited tools are available to quantify social engagement displayed by nursing home residents. Research suggests that intergenerational programming can positively affect social engagement. The present pilot study focused on the implementation of the Fun and Social Engagement (FUSE) evaluation to measure social engagement displayed by nursing home residents during Bingocize® sessions. The FUSE combined observation and self-report measures to yield a total social engagement score. …
Effects Of Evidence-Based Materials And Access To Local Resources On Physical Activity During Pregnancy, Kolbi Edens
Effects Of Evidence-Based Materials And Access To Local Resources On Physical Activity During Pregnancy, Kolbi Edens
Masters Theses & Specialist Projects
Physical activity (PA) during pregnancy has been shown to be safe and effective for improving maternal and infant health; however, only 23% of pregnant women exercise in accordance with guidelines. PURPOSE: To determine if the distribution of evidence-based educational resources as well as access to community resources will increase PA levels as well as knowledge/beliefs about PA during pregnancy. METHODS: Participants (8-12 weeks) completed assessments concerning their activity levels, as well as knowledge/beliefs regarding PA, during pregnancy. Next, participants were randomly assigned to either an intervention (IG) or control group (CG). The IG received educational information regarding PA during pregnancy, …
Ua66/6/3/1 Ogden College Of Science & Engineering Biology Student Organizations Alpha Epsilon Delta, Wku Archives
Ua66/6/3/1 Ogden College Of Science & Engineering Biology Student Organizations Alpha Epsilon Delta, Wku Archives
WKU Archives Collection Inventories
Records by and about Alpha Epsilon Delta.
Ua66/14/4 Ogden College Of Science & Engineering Nursing Allied Organizations, Wku Archives
Ua66/14/4 Ogden College Of Science & Engineering Nursing Allied Organizations, Wku Archives
WKU Archives Collection Inventories
Allied organizations associated with the Nursing Department including the Kentucky Partnership for Farm Family Health & Safety.