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Full-Text Articles in Medicine and Health Sciences
Stains Induce Apoptosis And Autophagy In Primary And Transformed Mast Cells, Patrick A. Paez
Stains Induce Apoptosis And Autophagy In Primary And Transformed Mast Cells, Patrick A. Paez
Theses and Dissertations
Statin drugs are widely employed in the clinic to reduce serum low density lipoproteins (LDLs) in patients with hypocholesteremia. In addition to their cholesterol-lowering effects through HMG CoA reductase antagonism, isoprenyl lipids necessary for membrane anchorage and signaling of small G-proteins are abrogated. We previously found that statins suppress mast cell activation in murine and human cells, suggesting these drugs might be useful in treating allergic disease. While mast cell function is critical to allergic inflammation, mast cell hyperplasia and survival also impact these diseases, and were not studied in our previous work. In this study, we describe Fluvastatin-mediated apoptosis …
The Effect Of Statins On Il-33 Mediated Mast Cell Function, Marcela Taruselli
The Effect Of Statins On Il-33 Mediated Mast Cell Function, Marcela Taruselli
Theses and Dissertations
This study demonstrates original findings of statin effects on IL-33 stimulated mast cells. Statins are a class of drugs used to lower cholesterol production by targeting HMG CoA reductase. These commonly prescribed drugs have been shown to be immunomodulatory. In this study, we have found that pretreatment with statins has a variety of effects on IL-33 stimulated mast cells. Atorvastatin suppresses TNF and IL-6 production, while fluvastatin significantly enhances release of these proinflammatory cytokines in BMMCs. Although they have differing effects on cytokine production, both statins lowered ST2 expression on the cell surface, decreased cell viability, and enhanced expression of …