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Articles 1 - 15 of 15
Full-Text Articles in Medicine and Health Sciences
The Influence Of Administrative Timing In Triple-Negative Breast Cancer Treatments, Emily Mailloux
The Influence Of Administrative Timing In Triple-Negative Breast Cancer Treatments, Emily Mailloux
Electronic Theses and Dissertations
Breast cancer accounts for 25% of all cancers in Canadian women, and 15-20% of these are triple-negative breast cancers (TNBC), which have a poorer prognosis than other breast cancer subtypes. TNBC lacks expression of the estrogen receptor, progesterone receptor, and the human epidermal growth factor receptor 2 (HER2), which are common therapeutic targets in breast cancer. Due to the lack of target therapy, generalized chemotherapy treatments are used instead. The standard of care for treatment of TNBC instead consists of doxorubicin (A), cyclophosphamide (C) paclitaxel (T), and carboplatin (Carbo), that target various aspects of the cell cycle to induce cell …
Studies Of Chemosensory Responses In The Pharynx Of The Sea Lamprey (Petromyzon Marinus), Hasan Huseyin Polat
Studies Of Chemosensory Responses In The Pharynx Of The Sea Lamprey (Petromyzon Marinus), Hasan Huseyin Polat
Electronic Theses and Dissertations
The sea lamprey is a basal vertebrate, and the oldest extant species with taste buds. The objective of this thesis was to study the chemosensory responses from the sea lamprey’s pharynx, which is located caudal to oral cavity and medial to seven lateral brachiopores. The pharynx contains taste buds that detect and respond to tastants to inform lampreys about gustatory factors in the environment. The location of these taste buds along the lateral surface of the pharynx was first determined using scanning electron microscopy. Then using electrophysiology, our recordings from these pharyngeal regions containing taste buds picked up responses from …
The Role Of The Circadian Clock In The Intestinal Epithelium During Health, Regeneration, And Tumourigenesis, Kyle Stokes
The Role Of The Circadian Clock In The Intestinal Epithelium During Health, Regeneration, And Tumourigenesis, Kyle Stokes
Electronic Theses and Dissertations
The Earth’s axial rotation subjects its surface to constant periods of light and dark, this is known as photoperiod. Many organisms have adapted their physiology in accordance with this environmental constant by generating 24h rhythms in their physiological functions; these are known as circadian rhythms. Circadian rhythms are controlled by an endogenous time-keeping mechanism known as the circadian clock. Over 40% of the genome in mice and over 80% of the genome in primates has been shown to have 24h rhythms in transcription. The disruption of circadian rhythms through shiftwork, jetlag, or exposure to light at night is associated with …
Physiological State Determinants Of Maternal Cortisol Signaling And Its Impact On Offspring Quality And Fitness, Sydney Currier
Physiological State Determinants Of Maternal Cortisol Signaling And Its Impact On Offspring Quality And Fitness, Sydney Currier
Electronic Theses and Dissertations
Assessing the intergenerational effects of maternal stress is important for predicting how offspring will respond to changing environments. The overall aim of my thesis was to quantify the effects of maternal state on maternally derived egg cortisol and determine whether this variation in egg cortisol impacts Chinook salmon offspring performance and fitness in a sex-specific way. I quantified within-female changes in maternal energetics and reproductive metrics that I linked to egg quality and ultimately embryo survival. I found egg cortisol increases with increasing maternal plasma cortisol, and increases further as plasma cortisol levels rise with each day that eggs are …
The Role Of The Nkr-P1b:Clr-B Inhibitory Axis In Nk Cell-Mediated Tumour Immunosurveillance, Abd El Aziz Hendy
The Role Of The Nkr-P1b:Clr-B Inhibitory Axis In Nk Cell-Mediated Tumour Immunosurveillance, Abd El Aziz Hendy
Electronic Theses and Dissertations
Natural killer (NK) cells are lymphocytes of the innate immune system which do not require prior priming to target infected or altered-self cells, such as tumour cells. The basic functions of NK cells include cytotoxicity and cytokine production. These cells possess numerous activating and inhibitory receptors which regulate their function based on a signalling balance. In mice, NK cells possess NKR-P1B inhibitory receptors which recognize the C-type lectin-related protein-b (Clr-b) ligand. This ligand is present on healthy self cells and may be used by cancer cells to evade NK cell effector functions. The disruption of the NKR-P1B:Clr-b axis has been …
An Enhancement To Cnn Approach With Synthesized Image Data For Disease Subtype Classification, Narider Pal Singh
An Enhancement To Cnn Approach With Synthesized Image Data For Disease Subtype Classification, Narider Pal Singh
Electronic Theses and Dissertations
The introduction of genetic testing has profoundly enhanced the prospects of early detection of diseases and techniques to suggest precision medicines. The subtyping of critical diseases has proven to be an essential part of the development of individualized therapies and has led to deeper insights into the heterogeneity of the disease. Studies suggest that variants in particular genes have significant effects on certain types of immune system cells and are also involved in the risk of certain critical illnesses like cancer. By analyzing the genetic sequence of a patient, disease types and subtypes can be predicted. Recent research work has …
A Program Evaluation Of Nutrition-Based Educational Modules Designed For The University Of Windsor Lancers Varsity Athletics, Justine Van Herk
A Program Evaluation Of Nutrition-Based Educational Modules Designed For The University Of Windsor Lancers Varsity Athletics, Justine Van Herk
Electronic Theses and Dissertations
The purpose of this program evaluation was to develop nutrition-based educational modules for the coaches and student-athletes at the University of Windsor and to investigate their effectiveness, usefulness, and applicability. The nutrition-based educational modules were a collaborative effort between the Community Health, Environment, and Wellness (CHEW) lab and the Centre for Human Performance and Health (CHPH). Eight teams voluntarily participated in the 6-week implementation period with the nutrition-based educational modules. Following this implementation period, nine participants (n = 2 coaches, n = 7 student-athletes) volunteered to provide feedback during one-on-one semi-structured virtual interviews. The interview guide was divided into …
A Network-Based Approach For Computational Drug Repurposing On Cancer Data, Ann Reba Thomas Alexander
A Network-Based Approach For Computational Drug Repurposing On Cancer Data, Ann Reba Thomas Alexander
Electronic Theses and Dissertations
In this thesis, we are interested in finding the best drugs that can be repurposed for the disease and able to find the adverse effects such drugs that are FDA-Approved. Developing an effective drug can be a time-consuming and expensive crucible method. Network-based machine learning methods are used for predicting a given drug for A that can be used for B. It aims at finding new indications for already existing drugs and therefore increases the available therapeutic choices at a fraction of the cost of new drug development. The perturbation gene expression data corresponding to the MCF7 cell line was …
Heredity In The Epigenetic Era: Are We Facing A Politics Of Reproductive Obligations?, Michael J. Crawford
Heredity In The Epigenetic Era: Are We Facing A Politics Of Reproductive Obligations?, Michael J. Crawford
Biological Sciences Publications
Recent research in the emerging field of epigenetics has implications with the potential to re-ignite acrimony in the discourse of reproductive rights, medical ethics, and the role of the state in our homes and in our lives. For scientists, epigenetics has profoundly realigned our understanding of heredity: epigenetics provides a mechanism through which the environmental challenges met in one generation can be inscribed and transmitted to future offspring. Although both genetic parents have the potential to transmit heritable epigenetic changes to their offspring, mothers have a particularly potent effect because nutrition in the uterine environment can exert a supplemental effect …
Fast Indication Of Bacterial Growth In Clinical Specimens By The Pmeu Approach, Elias Hakalehto, Anneli Heitto, Ilkka Pesola, Eva Del Amo, Heikki Paakkanen, Osmo Hänninen, Jouni Pesola
Fast Indication Of Bacterial Growth In Clinical Specimens By The Pmeu Approach, Elias Hakalehto, Anneli Heitto, Ilkka Pesola, Eva Del Amo, Heikki Paakkanen, Osmo Hänninen, Jouni Pesola
21st International Conference on Environmental Indicators (ICEI 2015)
No abstract provided.
The Potential Of Quinoline Derivatives For The Treatment Of Toxoplasma Gondii Infection., Sirinart Ananvoranich
The Potential Of Quinoline Derivatives For The Treatment Of Toxoplasma Gondii Infection., Sirinart Ananvoranich
Chemistry and Biochemistry Publications
Here we reported our investigation, as part of our drug repositioning effort, on anti-Toxoplasma properties of newly synthesized quinoline compounds. A collection of 4-aminoquinoline and 4-piperazinylquinoline analogs have recently been synthesized for use in cancer chemotherapy. Some analogs were able to outperform chloroquine, a quinoline derivative drug which is commonly used in the treatment of malaria and other parasitic infections. Herein 58 compounds containing one or two quinoline rings were examined for their effectiveness as potential anti-Toxoplasma compounds. Of these 58 compounds, 32 were efficient at inhibiting Toxoplasma growth (IC50μM). Five compounds with single and simple quinoline rings exhibited similar …
Older Athletes' Perceived Benefits Of Competition, Rylee A. Dionigi, Joseph Baker, Sean Horton
Older Athletes' Perceived Benefits Of Competition, Rylee A. Dionigi, Joseph Baker, Sean Horton
Human Kinetics Publications
Intense sport competition is typically associated with young people. Also, much of the literature on exercise for older adults focuses on benefits derived from regular physical activity, such as walking, dancing and fitness classes, and suggests that one should avoid extremely strenuous exercise. The rising phenomenon of older people competing in sport presents a challenge to these assumptions. In 2009, approximately 28,000 athletes from 95 countries gathered in Sydney, Australia to compete across 28 different sports at the World Masters Games. We interviewed 44 competitors (23 females, 21 males; aged 56-90 years; M=72) about what they gained from competing in …
Youth Ice Hockey Coaches' Perceptions Of A Team-Building Intervention Program, Julie Newin, Gordon A. Bloom, Todd M. Loughead
Youth Ice Hockey Coaches' Perceptions Of A Team-Building Intervention Program, Julie Newin, Gordon A. Bloom, Todd M. Loughead
Human Kinetics Publications
The purpose of the current study was to explain youth ice hockey coaches’ perceptions of the effectiveness of a team-building intervention program. Eight Peewee-level hockey coaches implemented the same team-building activities with their teams throughout the regular season. Data were gathered using 3 methods. Specifically, coaches answered questions on a pre-and postintervention form after each team-building activity, coaches’ behaviors were observed by members of the research team, and each coach completed a semistructured exit interview after the completion of the regular season. Results highlighted the benefits of the team-building intervention program. Specifically, coaches felt athletes enjoyed this experience and improved …
A Season-Long Team-Building Intervention: Examining The Effect Of Team Goal Setting On Cohesion, Julie Senecal, Todd M. Loughead, Gordon A. Bloom
A Season-Long Team-Building Intervention: Examining The Effect Of Team Goal Setting On Cohesion, Julie Senecal, Todd M. Loughead, Gordon A. Bloom
Human Kinetics Publications
The purpose of the current study was to determine whether the implementation of a season-long team-building intervention program using team goal setting increased perceptions of cohesion. The participants were 86 female high school basketball players from 8 teams. The teams were randomly assigned to either an experimental team goal–setting or control condition. Each participant completed the Group Environment Questionnaire (GEQ; Carron, Brawley, & Widmeyer, 2002; Carron, Widmeyer, & Brawley, 1985), which assessed cohesion at both the beginning and end of the season. Overall, the results revealed a significant multivariate effect, Pillai’s trace F(12, 438) = 2.68, p = .002. Post …
Maintenance Of Skilled Performance With Age: A Descriptive Examination Of Professional Golfers, Joseph Baker, Janice Deakin, Sean Horton, G. W. Pearce
Maintenance Of Skilled Performance With Age: A Descriptive Examination Of Professional Golfers, Joseph Baker, Janice Deakin, Sean Horton, G. W. Pearce
Human Kinetics Publications
Demographic studies indicate a remarkable aging trend in North America. An accurate profile of the decline in physical and cognitive capabilities over time is essential to our understanding of the aging process. This study examined the maintenance of skilled performance across the careers of 96 professional golfers. Data were collected on scoring average, driving distance, driving accuracy, greens in regulation, putts per round, and number of competitive rounds played using online data archives. Analyses indicate that performance in this activity can be maintained to a greater extent than in activities relying on biologically constrained abilities. Although the generalizability of these …