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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Ethyl Pyruvate Failed To Reduce Pro-Inflammatory Cytokines Release Following In Vitro Stimulation In Dairy Calves' Whole Blood., Vincent Dore
Doctoral Dissertations
Recent developments in sepsis treatment showed that control of the late mediator of inflammation, High Mobility Box group-1 (HMGB1), improves survival in animal models of endotoxemia. Ethyl pyruvate is a small-molecule inhibitor that has been shown to reduce the systemic release of HMGB1 during experimental treatment of systemic inflammation in different species. The objectives of this body of work were 1) to explore ethyl pyruvate's ability to modulate early pro-inflammatory cytokines production and immune effector function in treated calves, 2) to evaluate the safety of an administration of ethyl pyruvate infusion in neonatal calves, and 3) to explore ethyl pyruvate's …
Cryptosporidiosis In An Alpaca Cria Secondary To Prolongedantimicrobial Administration, Heidi M. Wyrosdick, Caroline Griffin, John J. Schaefer, Joseph Smith
Cryptosporidiosis In An Alpaca Cria Secondary To Prolongedantimicrobial Administration, Heidi M. Wyrosdick, Caroline Griffin, John J. Schaefer, Joseph Smith
Faculty Publications and Other Works -- Large Animal Clinical Sciences
No abstract provided.
Delayed Urethral Obstruction After Migration Of A Ballistic Pellet In An Alpine Wether, Joseph Smith
Delayed Urethral Obstruction After Migration Of A Ballistic Pellet In An Alpine Wether, Joseph Smith
Faculty Publications and Other Works -- Large Animal Clinical Sciences
A one-year-old alpine wether was presented for emergency evaluation of stranguria. Diagnostics identified a moderately distended bladder and mild dehydration. Preliminary lateral radiographs identified two metallic structures consistent with projectile pellets in the pelvic and perineal regions and no evidence of radiopaque uroliths. A tube cystostomy was performed, and a contrast urethrogram revealed one of the pellets in the perineal region was in proximity to the urethral obstruction. Subsequent radiography and ultrasound identified the pellet as being within the lumen of the urethra. Examination of the trichotomized skin revealed two scars, including a scar over the paralumbar fossa in the …
Pharmacokinetics Of Intramuscular Maropitant In Pigs (Sus Scrofa Domesticus), Joseph Smith, Jessica E. Gebert, Lisa S. Ebner, Kailee O. Bennett, Rebecca J. Collins, Chiara E. Hampton, Stephanie A. Kleine, Pierre-Yves Mulon, Christopher K. Smith, Reza Seddighi, Genevieve Bussieres, Jonathan P. Mochel, Healther K. Knych
Pharmacokinetics Of Intramuscular Maropitant In Pigs (Sus Scrofa Domesticus), Joseph Smith, Jessica E. Gebert, Lisa S. Ebner, Kailee O. Bennett, Rebecca J. Collins, Chiara E. Hampton, Stephanie A. Kleine, Pierre-Yves Mulon, Christopher K. Smith, Reza Seddighi, Genevieve Bussieres, Jonathan P. Mochel, Healther K. Knych
Faculty Publications and Other Works -- Large Animal Clinical Sciences
Pigs are at risk of vomiting from medical conditions as well as the emetic side effects of drugs administered for peri-operative manipulations, but there is a lack of pharmacokinetic data for potential anti-emetic therapies, such as maropitant, in this species. The main objective of this study was to estimate plasma pharmacokinetic parameters for maropitant in pigs after a single intramuscular (IM) administration dosed at 1.0 mg/ kg. A secondary objective was to estimate pilot pharmacokinetic parameters in pigs after oral (PO) administration at 2.0 mg/kg. Maropitant was administered to six commercial pigs at a dose of 1.0 mg/kg IM. Plasma …