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Laboratory and Basic Science Research
Loma Linda University Electronic Theses, Dissertations & Projects
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Full-Text Articles in Medicine and Health Sciences
Effects Of A Serine 364 To Proline Mutation Of The Connexin43 Protein In Transgenic Mice, Chia-Ling Nhan-Chang
Effects Of A Serine 364 To Proline Mutation Of The Connexin43 Protein In Transgenic Mice, Chia-Ling Nhan-Chang
Loma Linda University Electronic Theses, Dissertations & Projects
[Abstract Not Included]
Effects Of Liposome-Encapsulated Tnf-Alpha And Radiation Against Colon Cancer, Dong Won Kim
Effects Of Liposome-Encapsulated Tnf-Alpha And Radiation Against Colon Cancer, Dong Won Kim
Loma Linda University Electronic Theses, Dissertations & Projects
Previous studies have shown that tumor necrosis factor-α (TNF-α) can augment the antitumor effects of radiation, inhibiting tumor progression to a greater extent than either modality alone. However, nonspecific toxicities associated with TNF-α have limited its use as an adjuvant. This limitation is potentially resolved with the encapsulation of TNF-α in sterically stabilized, PEGylated liposomes (STEALTH®). Thus, the overall hypothesis of the research was that the combination of radiation with STEALTH® liposome encapsulated TNF-α (SL-TNF-α) will have greater efficacy and fewer dose-limiting side effects in the LS174T human colorectal tumor xenograft model compared to the combination of free TNF-α and …
Hard Tissue Forming Potential Of Mta Compared To Common Root-End Filling Materials, Nooshin Noghreian
Hard Tissue Forming Potential Of Mta Compared To Common Root-End Filling Materials, Nooshin Noghreian
Loma Linda University Electronic Theses, Dissertations & Projects
An ideal characteristic of root-end filling materials used in endodontics is the ability to enhance hard tissue formation. Studies have shown that MTA has the potential to enhance hard tissue formation when placed in contact with periradicular tissues. The mechanisms involved in hard tissue formation of MTA and other root-end filling materials have not been completely elucidated. The purpose of this investigation was to study the mechanism of hard tissue formation of commonly used root-end filling materials and MTA by evaluating alkaline phosphatase (ALP) activity and cell layer protein. Extracts of materials tested in this experiment were added to the …
The Effect Of Chronic Hypoxia On Cardiac Function In The Fetal Ovine Heart, Rodney David Rodrigo
The Effect Of Chronic Hypoxia On Cardiac Function In The Fetal Ovine Heart, Rodney David Rodrigo
Loma Linda University Electronic Theses, Dissertations & Projects
It has been shown that long-term high altitude hypoxia during pregnancy was associated with a decrease in cardiac contractility in fetal sheep. Given that hypoxia caused apoptotic cell death in fetal and neonatal rat cardiomyocytes, the present study tested the hypothesis that chronic hypoxia during pregnancy increases apoptosis in the fetal sheep heart. Pregnant (d 30) sheep were divided between normoxic control and chronically hypoxic (maintained at high altitude, 3,820 m, PaO2: 60 Torr for 110 days) groups. Hearts were isolated from near-term (d 140) fetal sheep, and samples from all four chambers, right and left atria, and …
Assessment Of Immune System Involvement In Tourette Syndrome, Ashley Dawn Levine
Assessment Of Immune System Involvement In Tourette Syndrome, Ashley Dawn Levine
Loma Linda University Electronic Theses, Dissertations & Projects
Tourette syndrome (TS) is currently hypothesized to be the result of genetic and immunological components. This study investigated whether TS subjects produce IgG and IgA antibodies that bind to caudate nucleus, hippocampus, frontal cortex, cerebellum, thalamus, globus pallidus interior, exterior and putamen. Thirty- two children (14 TS, 7 family control, and 11 non-family control) and thirty-nine adults (11 TS, 14 family control, and 14 non-family control) were studied. Immunofluorescent studies were performed on basal ganglia tissue using serum from TS children and their family members. Brain antigens were prepared as two fractions (supernatant and pellet) and used as targets for …