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Lymphoproliferative Disease In A Non-Transplant Patient And Spironolactone’S Activity Against Epstein Barr Virus, Anthony Derenzi, Jessie Penico
Lymphoproliferative Disease In A Non-Transplant Patient And Spironolactone’S Activity Against Epstein Barr Virus, Anthony Derenzi, Jessie Penico
HCA Healthcare Journal of Medicine
Epstein Barr Virus (EBV) may cause lymphoproliferative disorder that can cause malignancies in patients who are immunosuppressed. These malignancies may be suppressed or reversed by antiviral therapy including spironolactone.
We present a case of a 66-year-old female who had been immunosuppressed through use of interferon and tumor necrosis factor (TNF)-active agents for multiple sclerosis (MS). She met the criteria for idiopathic CD4 T-lymphocytopenia or non-human immunodeficiency syndrome (HIV) acquired immunodeficiency syndrome (AIDS). She developed a reactivation of EBV due to the immunosuppression which caused a subset of Non-Hodgkin’s lymphoma. The patient was initially treated with valacyclovir but she developed brain …