Medicine and Health Sciences Commons^™

Enhanced Detection Of Community-Acquired Pneumonia Pathogens With The Biofire® Pneumonia Filmarray® Panel., David Gilbert, James E Leggett, Lian Wang, Shirin Ferdosian, Gita D Gelfer, Michael L Johnston, Brent Footer, Kathryn W Hendrickson, Hiromichi Park, Emma White, John Heffner

Articles, Abstracts, and Reports

Background: Although most observational studies identify viral or bacterial pathogens in 50% or less of patients hospitalized with community-acquired pneumonia (CAP), we previously demonstrated that a multi-test bundle (MTB) detected a potential pathogen in 73% of patients. This study compares detection rates for potential pathogens with the MTB versus the Biofire® Pneumonia FilmArray® panel (BPFA) multiplex PCR platform and presents an approach for integrating BPFA results as a foundation for subsequent antibiotic stewardship (AS) activities.

Methods: Between January 2017 to March 2018, all patients admitted for CAP were enrolled. Patients were considered evaluable if all elements of the MTB and …

Defining The Proteolytic Landscape During Enterovirus Infection., Mohsan Saeed, Sebastian Kapell, Nicholas T Hertz, Xianfang Wu, Kierstin Bell, Alison W Ashbrook, Milica Tesic Mark, Henry A Zebroski, Maxwell L Neal, Malin Flodström-Tullberg, Margaret R Macdonald, John D Aitchison, Henrik Molina, Charles M Rice

Articles, Abstracts, and Reports

Viruses cleave cellular proteins to remodel the host proteome. The study of these cleavages has revealed mechanisms of immune evasion, resource exploitation, and pathogenesis. However, the full extent of virus-induced proteolysis in infected cells is unknown, mainly because until recently the technology for a global view of proteolysis within cells was lacking. Here, we report the first comprehensive catalog of proteins cleaved upon enterovirus infection and identify the sites within proteins where the cleavages occur. We employed multiple strategies to confirm protein cleavages and assigned them to one of the two enteroviral proteases. Detailed characterization of one substrate, LSM14A, a …

Are You Still On The Fence About Wearing A Mask?, Richard Davis

Articles, Abstracts, and Reports

Microbe-containing droplets are produced by coughing, talking, singing and sneezing. Masks are effective at blocking most of these droplets, even when up close.

Psjh Telehealth Covid-19 Repsonse, Todd Czartoski

Articles, Abstracts, and Reports

No abstract provided.

Projected Deaths Of Despair From Covid-19, Stephen Petterson, John M. Westfall, Benjamin F. Miller

Articles, Abstracts, and Reports

More Americans could lose their lives to deaths of despair, deaths due to drug, alcohol, and suicide, if we do not do something immediately. Deaths of despair have been on the rise for the last decade, and in the context of COVID-19, deaths of despair should be seen as the epidemic within the pandemic. The goal of this report is to predict what deaths of despair we might see based on three assumptions during COVID-19: economic recovery, relationship between deaths of despair and unemployment, and geography. Across nine different scenarios, additional deaths of despair range from 27,644 (quick recovery, smallest …

The Society For Immunotherapy Of Cancer Perspective On Regulation Of Interleukin-6 Signaling In Covid-19-Related Systemic Inflammatory Response, Fernanda I. Arnaldez, Steven J. O'Day, Charles G. Drake, Bernard A Fox, Bingqing Fu, Walter Urba, Vincenzo Montesarchio, Jeffrey S. Weber, Haiming Wei, Jon M. Wigginton, Paolo Antonio Ascierto

Articles, Abstracts, and Reports

The pandemic caused by the novel coronavirus SARS-CoV-2 has placed an unprecedented burden on healthcare systems around the world. In patients who experience severe disease, acute respiratory distress is often accompanied by a pathological immune reaction, sometimes referred to as ‘cytokine storm’. One hallmark feature of the profound inflammatory state seen in patients with COVID-19 who succumb to pneumonia and hypoxia is marked elevation of serum cytokines, especially interferon gamma, tumor necrosis factor alpha, interleukin 17 (IL-17), interleukin 8 (IL-8) and interleukin 6 (IL-6). Initial experience from the outbreaks in Italy, China and the USA has anecdotally demonstrated improved outcomes …

Covid-19 In The United States: Insights From Healthcare Systems, Aaron Harris, Nancy Foster, David Reich, Amy Compton-Phillips

Articles, Abstracts, and Reports

During this COCA Call, presenters will discuss the current impact of the COVID-19 pandemic on healthcare systems in the U.S., including key successes and challenges from the hospital response perspective.

Clinical Support: An Unconventional Request – Providence’S 100 Million Masks Initiative, Carrie Grinstead, Heather J. Martin, Laurie Schwing (Ed.)

Articles, Abstracts, and Reports

In early March, Seattle, WA, was the epicenter of the US COVID-19 pandemic. Providence St. Joseph Health had seen the first reported US case of COVID-19 on January 20 [1] and quickly found itself responding to a growing crisis, with little information about how best to care for patients while protecting frontline staff.

On March 16, 2020, Providence System Library Services received an email from senior leadership with the subject line: “Urgent – An Unconventional Request.” We were asked to pause all other work to search for viable mask patterns that could be easily and quickly made at home by …

Covid-19 Clinical Guidance For The Cardiovascular Care Team, Thomas M. Maddox, Eric C. Stecker, Biykem Bozkurt, Nathalie Demichelis, John U. Doherty, Andrew Freeman, Tyler J Gluckman, Dipti Itchhaporia, Andrew P. Miller, Andrea L. Price, Lonny Reisman, Prem Soman, Mohammad Madjid, Scott D. Solomon, Orly Vardeny

Articles, Abstracts, and Reports

COVID-19 is a quickly evolving public health emergency. The guidance provided in this document is based on the best available published information and expert evaluation. This document is intended to supplement, not supersede, relevant guidance from the Centers for Disease Control and Prevention, state and local health authorities, and your institution’s infectious disease containment, mitigation, and response plan.