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Full-Text Articles in Medicine and Health Sciences
Neonatal Gut Microbiota Alterations And Local Inflammation Induced By Escherichia Coli Infection Are Modified By Lactobacillus Rhamnosus Prophylaxis, Susana Chavez-Bueno, Hao Xuan, Shahid Umar, Concong Zhong, Wei Yu, Venkatesh Sampath
Neonatal Gut Microbiota Alterations And Local Inflammation Induced By Escherichia Coli Infection Are Modified By Lactobacillus Rhamnosus Prophylaxis, Susana Chavez-Bueno, Hao Xuan, Shahid Umar, Concong Zhong, Wei Yu, Venkatesh Sampath
Presentations
Background: E. coli is a leading cause of neonatal sepsis. Newborns ingest E. coli, which transcytoses the gut producing bacteremia. Lactobacillus spp. decrease E. coli gut transcytosis but the mechanisms involved in this protective effect are not well understood.
Objective: To determine the effects of Lactobacillus pretreatment on the intestinal microbiota and inflammation in neonatal rats orally infected with E. coli.
Design/Methods: Newborn rats were orally pretreated on day of life (DOL) 1 and 2 with four doses of 107 colony forming units (CFU) of Lactobacillus rhamnosus GG (LGG) or PBS. On DOL 2, pups received orally 106 CFU of …
Lessons From The Pandemic: How A Children’S Hospital Responded To The Challenges Of Covid-19, John Lantos, Paul Kempinski, Laurie Ellison, Jennifer Watts, Angela Myers
Lessons From The Pandemic: How A Children’S Hospital Responded To The Challenges Of Covid-19, John Lantos, Paul Kempinski, Laurie Ellison, Jennifer Watts, Angela Myers
Presentations
The COVID-19 pandemic challenged doctors and hospital administrators as did no other event in our lifetimes. Leaders needed to develop a pandemic command structure with the agility to respond to rapidly evolving situations. They had to deal with drastic financial implications, develop new methods of delivering health care, and collaborate regionally. They learned the importance of communication with staff, policy makers, the local medical community, and the public. They had to allocate of scarce resources internally and externally, and balancing rational policy making against irrational fears. For children’s hospitals, some specific challenges included determining our role in a pandemic that …
Impact Of A Mobile Device-Based Clinical Decision Support Tool On Guideline Adherence And Mental Workload Among Trainee And Attending Physicians, Katherine M. Richardson
Impact Of A Mobile Device-Based Clinical Decision Support Tool On Guideline Adherence And Mental Workload Among Trainee And Attending Physicians, Katherine M. Richardson
Presentations
This study evaluated PedsGuide, an app used to evaluate serious bacterial infections in febrile infants.