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Immunology and Infectious Disease
Microbiology, Immunology, and Molecular Genetics Faculty Publications
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- Animals (1)
- Antigen Presentation (1)
- Beta-Glucans (1)
- CD4-Positive T-Lymphocytes (1)
- Cytokines (1)
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- Dendritic Cells (1)
- Dendritic cells (1)
- Fungal infection (1)
- Gene Expression Regulation (1)
- Histocompatibility Antigens Class II (1)
- Lung defense (1)
- Lymphocyte Activation (1)
- Mice (1)
- Pathogen-Associated Molecular Pattern Molecules (1)
- Pneumocystis (1)
- Pneumocystis carinii (1)
- Pneumonia, Pneumocystis (1)
- T cells (1)
- Transcription Factors (1)
- Vaccines (1)
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
The Trophic Life Cycle Stage Of The Opportunistic Fungal Pathogen Pneumocystis Murina Hinders The Ability Of Dendritic Cells To Stimulate Cd4+ T Cell Responses, Heather M. Evans, Andrew Simpson, Shu Shen, Arnold J. Stromberg, Carol L. Pickett, Beth A. Garvy
The Trophic Life Cycle Stage Of The Opportunistic Fungal Pathogen Pneumocystis Murina Hinders The Ability Of Dendritic Cells To Stimulate Cd4+ T Cell Responses, Heather M. Evans, Andrew Simpson, Shu Shen, Arnold J. Stromberg, Carol L. Pickett, Beth A. Garvy
Microbiology, Immunology, and Molecular Genetics Faculty Publications
The life cycle of the opportunistic fungal pathogen Pneumocystis murina consists of a trophic stage and an ascus-like cystic stage. Infection with the cyst stage induces proinflammatory immune responses, while trophic forms suppress the cytokine response to multiple pathogen-associated molecular patterns (PAMPs), including β-glucan. A targeted gene expression assay was used to evaluate the dendritic cell response following stimulation with trophic forms alone, with a normal mixture of trophic forms and cysts, or with β-glucan. We demonstrate that stimulation with trophic forms downregulated the expression of multiple genes normally associated with the response to infection, including genes encoding …
Overcoming Hurdles To Development Of A Vaccine Against Pneumocystis Jirovecii, Beth A. Garvy
Overcoming Hurdles To Development Of A Vaccine Against Pneumocystis Jirovecii, Beth A. Garvy
Microbiology, Immunology, and Molecular Genetics Faculty Publications
Development of Pneumocystis pneumonia (PCP) is a common problem among immunosuppressed individuals. There are windows of opportunity in which vaccination would be beneficial, but to date, no vaccines have made it to clinical trials. Significant hurdles to vaccine development include host range specificity, making it difficult to translate from animal models to humans. Discovery of cross-reactive epitopes is critical to moving vaccine candidates from preclinical animal studies to clinical trials.