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Oncolog, Volume 61, Number 11-12, November - December 2016, Brandon C. Strubberg, Sarah Bronson, Stephanie Deming, E Nielsen

OncoLog MD Anderson's Report to Physicians (All issues)

• Innovative Trial Investigates Molecular Drivers of Triple-Negative Breast Cancer: A new clinical trial focusing on molecular biomarkers of triple-negative breast cancer (TNBC) is attempting to advance targeted therapy against the deadly disease.
• Smac Mimetics Show Activity against Myelofibrosis: Not all cases of myelofibrosis respond well to ruxolitinib, the only drug approved for this disease. However, early studies indicate that a new class of drugs, Smac mimetics, can achieve a response in some patients with myelofibrosis.
• Urothelial Cancer Subtypes Predict Treatment Response: Subtypes of urothelial cancer identified through gene expression profiling predict which patients are most likely to respond to neoadjuvant …

Oncolog, Volume 61, Number 10, October 2016, Laura L. Russell, Joe Munch, Bryan Tutt, Z Ahmed

OncoLog MD Anderson's Report to Physicians (All issues)

• Preventing Postoperative Urinary Tract Infections in Cancer Patients: Urinary tract infections (UTIs) increase morbidity, mortality and health care costs and prolong hospitalizations for patients who require urinary catheters-especially those who undergo long, complex surgeries or procedures to treat urological or gynecological cancers. To reduce the incidence of UTIs, clinicians at The University of Texas MD Anderson Cancer Center developed a quality improvement program for surgical patients at the institution.
• Study Offers a Starting Point for Testing Immunotherapy in Rectal Cancer Patients with Deficient DNA Mismatch Repair: A recent study's findings provide a starting point for assessing the efficacy of immunotherapy …

Oncolog, Volume 61, Number 09, September 2016, Jill Delsigne-Russell, Brandon C. Strubberg, E Nielsen

OncoLog MD Anderson's Report to Physicians (All issues)

• Transport Oncophysics Could Guide Pancreatic Cancer Treatment: Pancreatic ductal adenocarcinomas respond poorly to standard treatments. Researchers at The University of Texas MD Anderson Cancer Center are applying the principles of physics to characterize the tumors, and these analyses could lead to individualized therapy.
• Nivolumab Shows Potential in Treating Squamous Cell Carcinoma of the Anal Canal: Currently, there are no standard therapy options for patients with treatment-refractory metastatic squamous cell carcinoma of the anal canal (SCCA), but early results of a multi-institutional clinical trial (No. NCI9673) led by researchers at The University of Texas MD Anderson Cancer Center show that the …

Oncolog, Volume 61, Number 08, August 2016, Joe Munch, Bryan Tutt, E Nielsen

OncoLog MD Anderson's Report to Physicians (All issues)

• Finding a Way Forward in Parathyroid Carcinoma: Among the rarest of the rare malignancies, parathyroid carcinoma poses myriad diagnostic and treatment challenges. Owing to its extreme rarity, very little is known about the mechanisms driving parathyroid carcinoma, let alone how to target them; and survival rates have not budged in decades. However researchers at The University of Texas MD Anderson Cancer Center are working to change this.
• Studies Explore Screening for HPV-related Anal and Oropharyngeal Cancers: No consensus screening guidelines exist for human papillomavirus (HPV)-related cancers other than cervical cancer. As a step toward establishing such guidelines, studies under way …

Aisha, Aisha, Tsos

TSOS Interview Gallery

Aisha, a Syrian native, lived in Latakia with her Palestinian husband and six children. Their children were not allowed to attend school because of their Palestinian heritage. During the war, mortars and missiles hit the city, and Aisha's brother lost three children. Aisha's uncle in Jordan helped to smuggle their family into Turkey after they decided to escape.

They sailed to Greece with a boat carrying about 350 people. The ship's drivers abandoned it during the journey. To save the children on board, Aisha's husband steered the sinking ship. Her husband was arrested in Greece, and Aisha, who was five …

Samadi & Sabroo, Samadi, Sabroo, Tsos

TSOS Interview Gallery

Samadi was a member of the Kurdistan Freedom Party. He joined at the age of 17 andhas been a member for 22 years. This party sought an independent Kurdistan andfought with the invader countries. Samadi lived at the Oinofyat Refugee Camp inGreece at the time of this interview. His daughter was killed by ISIS in 2014 whiledefending Kurdistan. After her death, his family was threatened by the Salafi group.They left to save their lives. Samedi says that the Salafi group rapes and kills children in the name of religion. He says he is a fighter and he is not afraid …

Pamir And Rahila, Pamir, Rahila, Tsos

TSOS Interview Gallery

Pamir is from Afghanistan. He is a Hazarah, an ethnic minority group in Afghanistan. The Taliban hates his people. Nearly every member of his family has bullet wounds and war scars. His father was shot during the Mujahedin War and still has bullets in his leg. His older brother is blind in one eye and is still in Iran. His other brother was shot in the head and killed somewhere between the age of thirteen and fifteen. They escaped to Iran from Afghanistan, but the police caught Pamir and took him to a camp. They told him he could either …

Morena, Morena, Tsos

TSOS Interview Gallery

Morena has two children and a husband, and she is currently pregnant. Her life in Afghanistan felt normal, and she was able to study there until she had to flee. Her father in law was a truck driver for an American company and he had to surrender several vehicles to the Taliban. They robbed his vehicle and threatened violence. Because of this danger, Morena and her family fled. Their eight-month journey included rejection in Turkey and Iran multiple times and many struggles with smugglers and police. They eventually made it to a camp in Greece.

Because Morena is pregnant, they …

Madina, Madina, Tsos

TSOS Interview Gallery

Madina is from Afghanistan where she had a good life as a hairdresser. She loved her business and was very well off. She faced a great deal of opposition and persecution since she was a woman who owned a business. She faced violence and threats often. Eventually they were forced to sell their possessions and flee with the help of traffickers and had a dangerous and painful journey. Multiple times they were turned away at borders in Greece, Turkey, and Iran. Madina now lives in Oinofyta refugee camp with her husband and 6 children. Her husband has a disability due …

Tabish, Tabish, Tsos

TSOS Interview Gallery

Tabish is from Afghanistan. He fled the country because he had enemies there. He was shot multiple times during a Taliban raid, resulting in a broken leg and damaged hand. The bullets had to be pulled out with a stick. He and his family fled Afghanistan to Iran where the police threatened to arrest him for not having the legal papers to work. His family escaped to Turkey but were soon deported back to Iran. They eventually made it through after walking on foot for seven hours at the Turkish border. After spending five hours on the water on the …

Sangar & Nasira, Sangar, Nasira, Tsos

TSOS Interview Gallery

Sangar and his family are from Iran but are originally Turkish. In Iran they faced a psychological war and many problems that stemmed from discrimination. He points out how many are oppressed or discriminated against, but he and his family were singled out for their ethnicity. There was no hope for a bright future, and they decided to flee the country for the benefit of their children.

They fled to Greece through Turkey and had many issues with human traffickers, robbery, a treacherous journey across the sea, and problems in Moria refugee camp where his wife couldn’t get the care …

Aeham, Aeham, Tsos

TSOS Interview Gallery

Aeham Ahmad is a pianist from Yarmouk, Syria who gained internet fame from videos posted of him performing on the streets. Because of this, he was targeted and forced to flee to Germany, leaving his wife and two sons behind. Since this interview, his family has joined him.

Aeham’s talent and fame opened up opportunities to perform in various cities in Germany. To share his story during these performances, he learned English. He wants to use music to make a difference in the world. During his time in Yarmouk, there was an underground area where children practiced music because it …

Walid & Rahima, Walid, Rahima, Tsos

TSOS Interview Gallery

Walid worked as a police officer inBaghlan County,Afghanistan, where hedid many operations with NATO and US forces. Walid was responsible for recordingoperations and distributing copies to the media. Being part of the operations was dangerous, and Walid lost many of his friendsto the Taliban.Theyevenskinned afriend for cooperating with the government. The violenceled him to say, “The terrorists have no religion.” The Taliban began entering homes and killing government officials,and paid assassinations happened in public. Walidknew he was in danger.After losing a dear friend, Walid knew then that he had lost all he was willing to lose.He fled to Pakistan where …

Nevin, Nevin, Tsos

TSOS Interview Gallery

Nevin is a civil engineer from Afghanistan who worked with an American company and local government. The Taliban threatened him and demanded he work for them instead and ultimately attacked him on his journey home. After this he began a dangerous journey to Europe full of smugglers, trafficking, encounters with police, poor living conditions and a trip across the Mediterranean in an overcrowded raft.

Nevin ultimately made it to Greece, where he lived in a camp for several months. He received medical care but faced new problems of closed borders and difficulty obtaining papers. He was transferred to a camp …

Bahar And Zarrin, Bahar, Zarrin, Tsos

TSOS Interview Gallery

Bahar and Zarrin are friends living in Oinofyta Refugee Camp. They are both from Afghanistan but fled very different circumstances. Bahar lived in Iran with her husband until he passed, and she was rejected by her family. As a single woman she faced a life with little rights. Despite major health complications she fled to Greece in a boat. She now lives in the camp, struggling with repeated hospitalizations.

Zarrin left a life of comfort and privilege in Afghanistan and misses home greatly. Her husband was a wealthy businessman and Zarrin taught school. Thinking back on what they lost causes …

Ilhan & Family, Ilhan, Tsos

TSOS Interview Gallery

Ilhan, his wife Nura, and their children resided near Kabul, in a region where both the Taliban and ISIS were active. As Shias, Ilhan’s family faced numerous menaces, including threatsfrom ISIS that they would be beheaded if they did not display ISIS flags. Ilhan’s sister Radwa, who is deaf and mute, was forced to marry a regional leader. In addition to being threatened on religious grounds, Ilhan’s family was also threatened by anelder of their town. Out of desperation, Ilhan’s family sold their house appliances, escaped Afghanistan, and arrived at the Oinofyta refugee campin Greece. Ilhan’s family fled with Radwa, …

Kamaria Bakes, Kamaria, Twila Bird, Lindsay Silsby, Yasmine Kataw, Tsos

TSOS Interview Gallery

Amina is from Aleppo, where she was a math teacher. She is married with four boys. Her family fled to Turkey from Syria after losing their home in the war. Amina and her youngest son then sailed on an inflatable boat to Greece. Using cars, buses, and trains, they traveled from Greece to Macedonia, then on through Serbia, Croatia, Slovenia, and Austria before finally arriving in Germany. They stayed for two months in Camp Hamburg before being transferred for a short time to Lemberg. Lemberg was followed by another camp for three and a half months and then to Eisenberg …

Hamed, Hamed, Tsos

TSOS Interview Gallery

Hamed and his family are from Afghanistan where he worked as a diplomat and interpreter for the U.S. Army after having studied international relations and diplomacy. As the situation with the Taliban worsened it became too dangerous for Hamed and his family to stay in Afghanistan. They began the difficult journey with the help of smugglers, first to Iran, then Turkey, and then to Greece in a dangerous, overfilled boat.

Hamed explains the despair and frustration faced by many refugees. They feel as though very little is actually done for refugees once they’re admitted, and explains they need more assistance. …

Zarrin, Zarrin, Tsos

TSOS Interview Gallery

My name is Zarrin. I was an English teacher. In Afghanistan I had a big house and a garden. My husband was a rich man; he had lots of money. My children studied in a private school.All the time the Taliban was warning my husband, “Why does your wife go to school and teach children? If your wife goes to school, we’ll throw acid on her face and take your children.” They don’t like education —they don’t like women attending school.Zarrin left a life of comfort and privilege in Afghanistan and misses home greatly. Her husband was a wealthy businessman …

Oncolog, Volume 61, Number 07, July 2016, Bryan Tutt, Sarah Bronson, Laura Russell

OncoLog MD Anderson's Report to Physicians (All issues)

• Improving Rates of Vaccination after Hematopoietic Stem Cell Transplant: Patients who have undergone a hematopoietic stem cell transplant (HSCT) for a hematological cancer usually lose the immunity they had acquired through vaccination. Although guidelines exist for vaccinating immunocompromised transplant recipients, many patients go unvaccinated or do not complete the series of vaccinations. An ongoing initiative at The University of Texas MD Anderson Cancer Center is using a multipronged approach to improve rates of vaccination after HSCT.
• Bone Loss Prevention in Patients with Cancer: Patients undergoing cancer treatment are at an increased risk of fractures because many cancer therapies tend to …

Bahram & Camila, Bahram, Camila, Tsos

TSOS Interview Gallery

Bahram tells the story of the Afghanistan's 1992 government collapse and subsequent civil wars that destroyed the city of Kabul. "There was war in every alley, every house, every area and every village. 60,000 people were killed." Their family emigrated to Pakistan and after living there for some time, some relatives of a friend from their village travelled to Pakistan and required lodging so they stayed with Bahram's family. In some developing and under-developed countries, the custom of arranged marriage to child and infant daughters is practiced. These house guests demanded their one-year-old daughter be given in marriage to a …

Oncolog, Volume 61, Number 06, June 2016, Jill Deisigne, Joe Munch, Kathryn Hale, B Strubberg

OncoLog MD Anderson's Report to Physicians (All issues)

• Proton Therapy Trials May Provide More Options for Patients with Non-Small Cell Lung Cancer: Proton therapy offers the potential to deliver a higher radiation dose to lung tumors and a lower dose to healthy tissues than does standard radiation therapy. However, the effectiveness of proton therapy has not yet been documented in clinical trials for patients with non-small cell lung cancer (NSCLC), the most common type of lung cancer. Two ongoing trials of proton therapy aim to demonstrate its effectiveness and may change the standard of care for NSCLC.
• Innovative "Basket" Trial Shows Promise of BRAF Inhibition in Various Cancers: …

Oncolog, Volume 61, Number 05, May 2016, Bryan Tutt, Katelyn Werner

OncoLog MD Anderson's Report to Physicians (All issues)

• Intratumoral Therapies Offer Novel Cancer Treatment Approach: Injecting cancer treatments such as vaccines and genetically modified bacteria and viruses directly into tumors may shrink or destroy the tumors and stimulate an immune response that attacks tumor cells. These treatments have shown promise in clinical trials, and newer trials are exploring whether such treatments can augment the effectiveness of immunotherapy in patients with metastatic or inoperable disease.
• High-Risk Acute Lymphoblastic Leukemia Subtype Targeted in Upcoming Clinical Trial: Early T cell precursor acute lymphoblastic leukemia (ETP-ALL), an uncommon subtype of T cell acute lymphoblastic leukemia (T-ALL), carries a poor prognosis and low …

Oncolog, Volume 61, Number 04, April 2016, Joe Munch, Bryan Tutt, K Werner

OncoLog MD Anderson's Report to Physicians (All issues)

• Aggressive Multimodality Salvage Therapy for Locally Recurrent Rectal Cancer Offers Hope to Patients: For patients with locally recurrent rectal cancer, multimodality salvage therapy presents the only chance for a cure. Such therapy is offered at just a handful of specialized referral institutions, including The University of Texas MD Anderson Cancer Center.
• Rapid Assessment, Clinical Trials Could Improve Outcomes for Anaplastic Thyroid Cancer Patients: Anaplastic thyroid cancer is extremely aggressive-only 20% of patients survive 1 year after their diagnosis-so patients require immediate assessment and treatment. A program at The University of Texas MD Anderson Cancer Center expedites the care of patients …

Oncolog, Volume 61, Number 03, March 2016, Bryan Tutt, Sarah Bronson, Jill Deisigne, K Werner

OncoLog MD Anderson's Report to Physicians (All issues)

• Innovations Decrease Toxic Effects of Radiation Therapy for Mediastinal Tumors from Hematological Malignancies: Anterior mediastinal masses caused by lymphoma or leukemia can be difficult to treat because sensitive tissues in the area are vulnerable to damage from radiation therapy. To treat these tumors while sparing healthy tissue, radiation oncologists at The University of Texas MD Anderson Cancer Center use a combination of advanced technologies and new techniques.
• Transoral Robotic Surgery Enables Less Toxic Treatment of Early Throat Cancers: For decades, many patients with hard-to-reach throat cancers received high-dose radiation and chemotherapy, with their often severe toxic effects, because conventional surgery …

Lois Whaley Highsmith, Lois Whaley Highsmith, Kelsey Duinkerken

Jefferson Nursing Oral Histories

After originally studying chemical engineering at Penn State, Lois Highsmith decided to instead pursue nursing. At Jefferson she found a passion for community health nursing, specifically related to obstetrics, gynecology, and maternal child health. Ms. Highsmith graduated in 1986 and over the years worked mostly in maternal care but also in psychology. Among other positions, she worked for ten years at Pennsylvania Hospital where she founded STEPS, Strategies to Encourage Parental Self-Sufficiency, a teen pregnancy clinic, and worked as a home visitor for Mercy Home Health educating new moms about postpartum care. Since 2002 she has worked for Nurse Family …

Vera Paoletti, Vera Paoletti, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Vera Paoletti became interested in nursing as a teenager after watching a close family member succumb to leukemia. This experience led her to work as a candy striper at Jefferson Hospital through her high school years and then enroll in the Jefferson Hospital School of Nursing in 1966. Once she graduated in 1969 Ms. Paoletti began her career as a nurse at Jefferson, first in surgery on Ninth Pavilion and then in oncology on Eleventh Pavilion before becoming head nurse first of a nineteen-bed unit reserved for VIPs and then two years later of Sixth Main. In 1975 she left …

Joan Walker Randolph, Joan Walker Randolph, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Joan Randolph is a 1956 graduate of the Jefferson School of Nursing’s Diploma Program. Though she enjoyed all of her nursing rotations as a student, upon graduation she decided to go into medical-surgical nursing, starting her career at Jefferson Hospital working with, among others, Dr. John Gibbon. After leaving Jefferson, Ms. Randolph spent the bulk of her career at Jeanes Hospital, where she worked her way up from staff nurse to head nurse and eventually on to Vice President of Patient Care Services. Though now retired Ms. Randolph continues to be involved with the field of nursing by serving on …

Colleen Young Elwood, Colleen Young Elwood, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Colleen Young Elwood discovered her interest in nursing after finishing a Bachelor’s of Science in psychology and starting her career at Juvenile Diabetes Research Foundation. Learning about diabetes and working with diabetics sparked an interest in public and community health so she enrolled in Thomas Jefferson University’s two-year BSN program, which she graduated from in 2013. While at Jefferson her clinical experiences confirmed she was not interested in hospital nursing but instead in community nursing. After graduating she started working at Nurse Family Partnership, first as an intern and then as a Nurse-Home Visitor, where she helps new mothers during …

Oncolog, Volume 61, Number 02, February 2016, Joe Munch, Bryan Tutt, C Graber

OncoLog MD Anderson's Report to Physicians (All issues)

• Overcoming Challenges in Cutaneous T Cell Lymphomas: Cutaneous T Cell lymphomas (CTCLs) not only are largely incurable but also make patients miserable with itching, burning skin and unsightly lesions. Because CTCL can resemble various benign skin conditions, many patients are diagnosed at an advanced and difficult-to-treat stage. But ongoing clinical trials may offer patients with CTCL improved treatments and better quality of life.
• Swallowing Therapy Improves Function and Quality of Life for Patients with Head and Neck Cancer: In patients with head and neck cancer, loss of swallowing function may result from radiation therapy, surgery, or the cancer itself and …