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Antimicrobial Resistance In Eskape Pathogens And Its Effect On Modern Medicine And Treatment, Cameran Runge

Honors Theses

Abstract

ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella

pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter

spp.) are seeing a growing resistance to multiple classes of antibiotics. Misuse and overuse of antibiotics have played directly into the resistance observed, and the problem is growing exponentially. Antibiotic resistance is partially due to several intrinsic factors limiting the drug's uptake. These include efflux pumps, increased biofilm production, and reduced cell wall permeability in the resistant bacteria. ESKAPE pathogens also acquire resistance through horizontal gene transfer and plasmids. As antibiotics have become less effective, the bacteria can continue to thrive, leading to a detrimental …

Plpt 496/892: Disease Dynamics & Evolution—A Peer Review Of Teaching Project Benchmark Portfolio, Sydney E. Everhart

UNL Faculty Course Portfolios

This benchmark course portfolio was developed as a component of the University of Nebraska Peer Review of Teaching. The course selected for this portfolio was a new course developed and taught as an Independent Study PLPT 496/892. The working title for the course was Disease Dynamics and Evolution. This course was designed to cover core concepts of disease ecology and pathogen emergence/evolution. Concepts were organism-agnostic and important for understanding infectious diseases of humans, animals, and plants. The course format was lecture-based and inquiry driven, using primary literature as case studies. The goal of this course was to use interesting and …