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Hospital Change To Mixed Lipid Emulsion From Soybean Oil-Based Lipid Emulsion For Parenteral Nutrition In Hospitalized And Critically Ill Adults Improves Outcomes: A Pre-Post-Comparative Study, Krista L Haines, Tetsu Ohnuma, Charles Trujillo, Obanor Osamudiamen, Vijay Krishnamoorthy, Karthik Raghunathan, Paul E Wischmeyer
Hospital Change To Mixed Lipid Emulsion From Soybean Oil-Based Lipid Emulsion For Parenteral Nutrition In Hospitalized And Critically Ill Adults Improves Outcomes: A Pre-Post-Comparative Study, Krista L Haines, Tetsu Ohnuma, Charles Trujillo, Obanor Osamudiamen, Vijay Krishnamoorthy, Karthik Raghunathan, Paul E Wischmeyer
Faculty and Staff Publications
INTRODUCTION: Early data suggest use of a mixed lipid emulsion (LE) with a soybean oil reduction strategy in parenteral nutrition (PN) may improve clinical outcomes. Duke University Hospital made a full switch to a Soybean oil/MCT/Olive/Fish Oil lipid (4-OLE) from pure soybean oil-based LE (Intralipid, Baxter Inc) in May 2017. Since 4-OLE has limited evidence related to its effects on clinical outcome parameters in US hospitals, evidence for clinical benefits of switching to 4-OLE is needed. Therefore, we examined the clinical utility of a hospital-wide switch to 4-OLE and its effect on patient outcomes.
METHODS: We conducted a single-center retrospective …