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Vitamin D Mitigates Age-Related Cognitive Decline Through The Modulation Of Pro-Inflammatory State And Decrease In Amyloid Burden, Teresita L. Briones, Hala Darwish

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Increasing evidence shows an association between the use of vitamin D and improvement in age-related cognitive decline. In this study, we investigated the possible mechanisms involved in the neuroprotective effects of vitamin D on age-related brain changes and cognitive function.

Methods

Male F344 rats aged 20 months (old) and 6 months (young) were used and randomly assigned to either vitamin D supplementation or no supplementation (control). A total of n = 39 rats were used in the study. Rats were individually housed and the supplementation group received a subcutaneous injection of vitamin D (1, α25-dihydroxyvitamin D3) 42 I.U./Kg …

Ethnicity And Lifetimes: Self Concepts And Situational Contexts Of Ethnic Identity In Late Life, Mark Luborsky, Robert L. Rubinstein

Anthropology Faculty Research Publications

This chapter reports on finding from a study of ethnic older men, aged 65 an older (Jewish, Irish, and Italian) who were widowed from 2 to 8 years after a long-term study. It focuses on life reorganization after the initial bereavement period. It identifies key issues in the process concerning continuity and change in identity reformulation, changes in health and activity patterns, ethnic identity and lingering attachment to the deceased spouse. Ethnicity as a dynamic life course process, shaped by contextual and historical dimensions, and personal meaning processes are highlighted. Supported by NIH# R01-AG005204