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Full-Text Articles in Medicine and Health Sciences
Comparison Of The Hui3 And The Eq-5d-3l In A Nursing Home Setting, Tom Lung, Kirsten Howard, Christopher Etherton-Beer, Moira Sim, Gill Lewin, Glenn Arendts
Comparison Of The Hui3 And The Eq-5d-3l In A Nursing Home Setting, Tom Lung, Kirsten Howard, Christopher Etherton-Beer, Moira Sim, Gill Lewin, Glenn Arendts
Research outputs 2014 to 2021
Background:
Accurately assessing changes in the quality of life of older people living permanently in nursing homes is important. The multi-attribute utility instrument most commonly used and recommended to assess health-related quality of life in the nursing home population is the three-level EuroQol EQ-5D-3L. To date, there have been no studies using the Health Utilities Index Mark III (HUI3). The purpose of this study was to compare the level of agreement and sensitivity to change of the EQ-5D-3L and HUI3 in a nursing home population.
Methods:
EQ-5D-3L and HUI3 scores were measured as part of a cluster randomised controlled trial …
Regulation Of Core Body Temperature And The Immune System Determines Species Longevity, Ian J. Martins
Regulation Of Core Body Temperature And The Immune System Determines Species Longevity, Ian J. Martins
Research outputs 2014 to 2021
The anti-aging gene Sirtuin 1 has now major relevance to genetics and the fields of pharmacology, toxicology, neuroscience, immunology, biochemistry and cell/molecular biology. Advances in anti-aging therapy are now essential to prevent mitochondrial apoptosis to promote longevity with the prevention of accelerated ageing. Calorie restriction that maintains the anti-aging gens changes the core body temperature and promotes species longevity. Stress and calorie consumption are sensitive to Sirt 1 function with relevance heat shock protein 70 metabolism and mitochondrial biogenesis. Sirt 1 regulation of the circadian rhythm mediates melatonin effects on core body temperature regulation and immune responses. Diet and fat …
Amyloid Β–Associated Cognitive Decline In The Absence Of Clinical Disease Progression And Systemic Illness, Karra Harrington, Yen Lim, David Ames, Jason Hassenstab, Simon Laws, Ralph Martins, Stephanie Rainey-Smith, Joanne Robertson, Christopher Rowe, Olivier Salvado, Vincent Dore, Victor Villemagne, Peter Snyder, Colin Masters, Paul Maruff, Aibl Research Group
Amyloid Β–Associated Cognitive Decline In The Absence Of Clinical Disease Progression And Systemic Illness, Karra Harrington, Yen Lim, David Ames, Jason Hassenstab, Simon Laws, Ralph Martins, Stephanie Rainey-Smith, Joanne Robertson, Christopher Rowe, Olivier Salvado, Vincent Dore, Victor Villemagne, Peter Snyder, Colin Masters, Paul Maruff, Aibl Research Group
Research outputs 2014 to 2021
Introduction
High levels of amyloid β (Aβ) are associated with cognitive decline in cognitively normal (CN) older adults. This study investigated the nature of cognitive decline in healthy individuals who did not progress to mild cognitive impairment or dementia.
Method
Cognition was measured over 72 months and compared between low (Aβ−) and high (Aβ+) CN older adults (n = 335) who did not progress to mild cognitive impairment or dementia and who remained free of severe or uncontrolled systemic illness.
Results
Compared to the Aβ− group, the Aβ+ group showed no cognitive impairment at baseline but showed substantial decline …