Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
The Effect Of Dna Methylation On Tp73 Expression In Tumorgenesis, Nujuma A. Moussa
The Effect Of Dna Methylation On Tp73 Expression In Tumorgenesis, Nujuma A. Moussa
Undergraduate Research Posters
Abstract: The Effect of DNA Methylation on TP73 Expression in Tumorgenesis
Nujuma Moussa, Zhixing Yao, Zaki A. Sherif
Department of Biochemistry & Molecular Biology, Howard University College of Medicine
TP73 is a member of the TP53 family of proteins that acts as a transcription factor to help regulate cellular distress. This tumor protein may play a dual role as a tumor suppressor and tumor promoter. The TP73 gene is mapped to chromosome 1p36, a frequently deleted region in neuroblastoma and other types of tumors. While mutations in the TP53 gene are commonly known to cause noxious cancers, 30% of cancers …