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Full-Text Articles in Medicine and Health Sciences
Fecal Microbiota Transplantation In Parkinson's Disease-A Randomized Repeat-Dose, Placebo-Controlled Clinical Pilot Study, Herbert L Dupont, Jessika Suescun, Zhi-Dong Jiang, Eric L Brown, Heather T Essigmann, Ashley S Alexander, Andrew W Dupont, Tehseen Iqbal, Netanya S Utay, Michael Newmark, Mya C Schiess
Fecal Microbiota Transplantation In Parkinson's Disease-A Randomized Repeat-Dose, Placebo-Controlled Clinical Pilot Study, Herbert L Dupont, Jessika Suescun, Zhi-Dong Jiang, Eric L Brown, Heather T Essigmann, Ashley S Alexander, Andrew W Dupont, Tehseen Iqbal, Netanya S Utay, Michael Newmark, Mya C Schiess
Journal Articles
BACKGROUND AND PURPOSE: The intestinal microbiome plays a primary role in the pathogenesis of neurodegenerative disorders and may provide an opportunity for disease modification. We performed a pilot clinical study looking at the safety of fecal microbiota transplantation (FMT), its effect on the microbiome, and improvement of symptoms in Parkinson's disease.
METHODS: This was a randomized, double-blind placebo-controlled pilot study, wherein orally administered lyophilized FMT product or matching placebo was given to 12 subjects with mild to moderate Parkinson's disease with constipation twice weekly for 12 weeks. Subjects were followed for safety and clinical improvement for 9 additional months (total …