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Type I Interferons Protect From Toll-Like Receptor 9-Associated Liver Injury And Regulate Il-1 Receptor Antagonist In Mice, Jan Petrasek, Angela Dolganiuc, Timea Csak, Evelyn Kurt-Jones, Gyongyi Szabo
Type I Interferons Protect From Toll-Like Receptor 9-Associated Liver Injury And Regulate Il-1 Receptor Antagonist In Mice, Jan Petrasek, Angela Dolganiuc, Timea Csak, Evelyn Kurt-Jones, Gyongyi Szabo
Gyongyi Szabo
BACKGROUND and AIMS: Liver inflammation and injury are mediated by the innate immune response, which is regulated by Toll-like receptors (TLR). Activation of TLR9 induces type I interferons (IFNs) via the interferon regulatory factor (IRF)-7. We investigated the roles of type I IFNs in TLR9-associated liver injury. METHODS: Wild-type (WT), IRF7-deficient, and IFN-alpha/beta receptor 1 (IFNAR1)-deficient mice were stimulated with TLR9 or TLR2 ligands. Findings from mice were verified in cultured hepatocytes and liver mononuclear cells (LMNCs) as well as in vivo experiments using recombinant type I IFN and interleukin-1 receptor antagonist (IL-1ra). RESULTS: Type I IFNs were up-regulated during …