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Identifying Mediators, Moderators And High-Risk Latent Classes Of Preterm Birth And Low Birth Weight Among Pregnant Women In Rural Mysore, India, Sandra Kiplagat

FIU Electronic Theses and Dissertations

This dissertation examined the mediators, moderators, and high-risk latent classes of preterm birth (PTB) and low birth weight (LBW) among pregnant women in rural Mysore District, India. Secondary data analyses of a prospective cohort study conducted between 2011-2014 among 1540 women was performed to complete this dissertation.

In the first study, we examined the association between socioeconomic status (SES) and PTB and LBW. Latent class analysis (LCA) was performed to assess sociodemographic patterns of high-risk pregnant women based on education, income, marital status, primigravida status and number of children. We identified four distinct classes, Class 1 “low SES/early marriage/multigravida/1 child …

Can Racial Disparities In Poor Birth Outcomes Be Partially Attributed To Stress: A Mendellian Randomization Study, Madeline Travers

Dissertations and Theses

In the United States, low birth weight (LBW) is a leading cause of infant death overall, and the leading cause of death for Black infants. Understanding and preventing adverse birth outcomes is a major public health priority. Observationally, there is some evidence to support the hypothesis that maternal stress may be associated with LBW. To clarify the effect of maternal stress exposure on LBW, I conducted three separate-sample instrumental variable analyses with genetic instruments (Mendelian randomization) based on single nucleotide polymorphisms (SNP), from genome wide association studies, strongly (p-value < 5 × 10⁻⁶) and independently associated with neuroendocrine, vascular, and immune measures …