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Perioperative Beta-Blocker Therapy And Mortality After Major Noncardiac Surgery, Peter K. Lindenauer, Penelope Susan Pekow, Kaijun Wang, Dheeresh K. Mamidi, Benjamin Gutierrez, Evan M. Benjamin
Perioperative Beta-Blocker Therapy And Mortality After Major Noncardiac Surgery, Peter K. Lindenauer, Penelope Susan Pekow, Kaijun Wang, Dheeresh K. Mamidi, Benjamin Gutierrez, Evan M. Benjamin
Peter Lindenauer MD
Background: Despite limited evidence from randomized trials, perioperative treatment with beta-blockers is now widely advocated. We assessed the use of perioperative beta-blockers and their association with in-hospital mortality in routine clinical practice.
Methods: We conducted a retrospective cohort study of patients 18 years of age or older who underwent major noncardiac surgery in 2000 and 2001 at 329 hospitals throughout the United States. We used propensity-score matching to adjust for differences between patients who received perioperative beta-blockers and those who did not receive such therapy and compared in-hospital mortality using multivariable logistic modeling.
Results: Of 782,969 patients, 663,635 (85 percent) …