Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Effects Of L-Fucose Supplementation On The Viability Of Cancer Cell Lines, Muhammad Alif Mazlan, Afzan Mat Yusof, Muhammad Lokman Md Isa
Effects Of L-Fucose Supplementation On The Viability Of Cancer Cell Lines, Muhammad Alif Mazlan, Afzan Mat Yusof, Muhammad Lokman Md Isa
Makara Journal of Health Research
Background: Fucose is a deoxyhexose sugar. While the biological roles of L-fucose remain unclear, the sugar is known to accelerate the malignant potential of cancer cells. Therefore, this study aimed to evaluate the viability pattern of human cancer and normal cell lines treated with fucose.
Methods: The human gingival fibroblast (HGF-1), colorectal adenocarcinoma (HT-29) and skin malignant melanoma (A375) cell lines were cultured and treated with fucose at three concentrations of 1, 5, and 10 mg/ml. Cell viability was then measured using (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay. The data were analyzed using Statistical Package for the Social …