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Full-Text Articles in Medicine and Health Sciences
Refining Associations Between Targeted Genes And The Development Of Substance Use Disorders, Emily Olfson
Refining Associations Between Targeted Genes And The Development Of Substance Use Disorders, Emily Olfson
Arts & Sciences Electronic Theses and Dissertations
Recent genome-wide association studies (GWAS) provide strong evidence for the contribution of a few specific genes to alcohol and nicotine dependence. Chapter 2 explores numerous previously identified candidate genes for alcohol dependence using a publicly available GWAS. I found that many candidate loci do not replicate, highlighting the utility of GWAS for focusing on disease associated genes. Chapters 3-5 dissect associations between three genome-wide significant genes and substance use disorders. Chapter 3 focuses on a functional variant in alcohol dehydrogenase (ADH) 1B. Through examining 1,550 adolescent drinkers in the Collaborative Study on the Genetics of Alcoholism (COGA), I extended adult …
Four Essays In Education And Epidemiology, Brittni Danielle Jones
Four Essays In Education And Epidemiology, Brittni Danielle Jones
Arts & Sciences Electronic Theses and Dissertations
This dissertation includes four, co-authored essays in which social epidemiological concepts and methods were applied to explore the nexus of race, education, and health in the United States. In the first two essays, colleagues and I employed geospatial mapping and analysis to examine the association between past, racially segregative, housing practices and the geospatial distribution of poor, education, health, and related developmental outcomes across Ferguson, Missouri, and the surrounding St. Louis metropolitan region. We investigated this association during two, respective cross-sections of time. Results revealed the nature and distribution of class and racial disparities across the region. Based on the …