Medicine and Health Sciences Commons^™

An Ace2 Decamer Viral Trap As A Durable Intervention Solution For Current And Future Sars-Cov, Hailong Guo, Bomsoo Cho, Paul R Hinton, Sijia He, Yongjun Yu, Ashwin Kumar Ramesh, Jwala Priyadarsini Sivaccumar, Zhiqiang Ku, Kristen Campo, Sarah Holland, Sameer Sachdeva, Christopher Mensch, Mohamed Dawod, Annalis Whitaker, Philip Eisenhauer, Allison Falcone, Rebekah Honce, Jason W Botten, Stephen F Carroll, Bruce A Keyt, Andrew W Womack, William R Strohl, Kai Xu, Ningyan Zhang, Zhiqiang An, Sha Ha, John W Shiver, Tong-Ming Fu

Student and Faculty Publications

The capacity of SARS-CoV-2 to evolve poses challenges to conventional prevention and treatment options such as vaccination and monoclonal antibodies, as they rely on viral receptor binding domain (RBD) sequences from previous strains. Additionally, animal CoVs, especially those of the SARS family, are now appreciated as a constant pandemic threat. We present here a new antiviral approach featuring inhalation delivery of a recombinant viral trap composed of ten copies of angiotensin-converting enzyme 2 (ACE2) fused to the IgM Fc. This ACE2 decamer viral trap is designed to inhibit SARS-CoV-2 entry function, regardless of viral RBD sequence variations as shown by …

Factors Associated With Mask Use In New York City Neighborhood Parks During The Covid-19 Pandemic: A Field Audit Study, Lisa Hitch, Marie A. Sillice, Hanish Kodali, Katarzyna E. Wyka, Javier Otero Peña, Terry Tk Huang

Publications and Research

Background: Mask use is a cost-effective measure to decrease COVID-19 transmission. Mask mandates intend to increase mask compliance but are often ambiguous when it comes to public outdoor spaces.

Methods: We used a field audit study to examine mask use in New York City neighborhood parks during COVID-19. 1453 park visitors were observed in 13 parks during July–August 2020 using a modified and validated park use audit tool (System for Observing Play and Recreation in Communities) that included items on general and proper mask use (i.e., mask covering both nose and mouth). Generalized estimating equation regression was used to determine …

"Don't Know Where To Go For Help": Safety And Economic Needs Among Violence Survivors During The Covid-19 Pandemic, Leila Wood, Elizabeth Baumler, Rachel Voth Schrag, Shannon Guillot-Wright, Dixie Hairston, Jeff Temple, Elizabeth Torres

Student and Faculty Publications

The COVID-19 pandemic and related quarantine has created additional problems for survivors of interpersonal violence. The purpose of this study is to gain a preliminary understanding of the health, safety, and economic impacts of the COVID-19 pandemic on people that are experiencing or have previously experienced violence, stalking, threats, and/or abuse. An online survey, open from April to June 2020, was taken by people with safety concerns from interpersonal violence. Participants were recruited from IPV and sexual assault-focused agencies, state coalitions, and social media. Quantitative data were summarized using descriptive methods in SPSS and coding methods from thematic and content …

Development Of A Bamlanivimab Infusion Process In The Emergency Department For Outpatient Covid-19 Patients, Danny Pham, Sandy Wong, Christina T. Nguyen, Stephen C. Lee, Kimberly J. Won

Pharmacy Faculty Articles and Research

The coronavirus disease 2019 (COVID-19) pandemic has prompted the creation of new therapies to help fight against the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Bamlanivimab is a SARS-CoV-2 monoclonal antibody that is administered as an intravenous infusion to ambulatory patients with mild or moderate COVID-19, but a concern that arose was deciding the optimal location for patients to receive the medication. This report describes the development and implementation of a bamlanivimab infusion center in the emergency department of three hospitals in Orange County, California, shortly after bamlanivimab received emergency use authorization. As a result, a total of 601 …

Ua19/16/2 Women's Basketball Press Releases, Wku Athletic Media Relations

WKU Archives Records

Press releases, photos and game statistics for WKU women's basketball team from August to December 2021.

Ua19/16/2 Basketball Press Releases, Wku Athletic Media Relations

WKU Archives Records

Press releases, photos and game statistics for WKU basketball team from August to December 2021.

Ua94/6/1 Pandemic Personal Narrative, Leah Painter

Student/Alumni Personal Papers

COVID-19 personal narrative written by student Leah Painter for History 241 class.

Meeting Minutes, Wku Council Of Academic Deans

Council of Academic Deans

Meeting regarding post-COVID instructional modality and international travel.

Suppression Of Human Coronavirus 229e Infection In Lung Fibroblast Cells Via Rna Interference, Hamidreza Montazeri Aliabadi, Jennifer Totonchy, Parvin Mahdipoor, Keykavous Parang, Hasan Uludağ

Pharmacy Faculty Articles and Research

Despite extensive efforts to repurpose approved drugs, discover new small molecules, and develop vaccines, COVID-19 pandemic is still claiming victims around the world. The current arsenal of antiviral compounds did not perform well in the past viral infections (e.g., SARS), which casts a shadow of doubt for use against the new SARS-CoV-2. Vaccines should offer the ultimate protection; however, there is limited information about the longevity of the generated immunity and the protection against possible mutations. This study uses Human Coronavirus 229E as a model coronavirus to test the hypothesis that effective delivery of virus-specific siRNAs to infected cells will …

Ua94/6/1 Covid-19 Diary, Kaleb Workman

Student/Alumni Personal Papers

Reflections of COVID-19 by Gatton Academy of Mathematics & Science student Kaleb Workman.

Ua19/16/2 Women's Basketball Press Releases, Wku Athletic Media Relations

WKU Archives Records

Press releases, photos and game statistics for WKU women's basketball team in 2021.

Ua19/16/2 Basketball Press Releases, Wku Athletic Media Relations

WKU Archives Records

Press releases, photos and game statistics for WKU basketball team from January to July 2021.

Sars-Cov-2 Transmission In Alberta, British Columbia, And Ontario, Canada, December 25, 2019, To December 1, 2020, Isaac Chun-Hai Fung, Yuen Wai Hung, Sylvia Ofori, Kamalich Muniz-Rodriguez, Po-Ying Lai, Gerardo Chowell

Department of Biostatistics, Epidemiology, and Environmental Health Sciences Faculty Publications

Objective:

This study aimed to investigate coronavirus disease (COVID-19) epidemiology in Alberta, British Columbia, and Ontario, Canada.

Methods:

Using data through December 1, 2020, we estimated time-varying reproduction number, R t , using EpiEstim package in R, and calculated incidence rate ratios (IRR) across the 3 provinces.

Results:

In Ontario, 76% (92 745/121 745) of cases were in Toronto, Peel, York, Ottawa, and Durham; in Alberta, 82% (49 878/61 169) in Calgary and Edmonton; in British Columbia, 90% (31 142/34 699) in Fraser and Vancouver Coastal. Across 3 provinces, R t dropped to ≤ 1 after April. …

Meeting Minutes, Wku Council Of Academic Deans

Council of Academic Deans

Meeting regarding eSports, first destination survey, Respondus Monitor, DELO funds, graduate assistant instructors, salaries and working remotely.

Meeting Minutes, Wku Council Of Academic Deans

Council of Academic Deans

Meeting regarding graduate fair, commencement, enrollment, accreditation, zoom connect classroom and fifth week assessment.

Meeting Minutes, Wku Council Of Academic Deans

Council of Academic Deans

Meeting regarding accreditation, Colonnade director, academic program review, pass grade numbers, provost search, micro-credentials, graduate admission standards, graduate-level prior learning assessment, travel policy and cross-listed courses merging on Blackboard.

Ua94/6/1 Covid-19: The New Plague, Kaylene Bliss

Student/Alumni Personal Papers

COVID-19 personal narrative written by student Kaylene Bliss for History 241 class.

Ua19/16/2 Soccer Press Releases, Wku Athletic Media Relations

WKU Archives Records

Press releases, photos and game statistics for WKU soccer team in 2021.

Ua19/16/2 Softball Press Releases, Wku Athletic Media Relations

WKU Archives Records

Press releases, photos and game statistics for WKU softball team in 2021.

The Intellectual Property Of Covid-19, Ana Santos Rutschman

All Faculty Scholarship

The response to COVID-19 is indissolubly tied to intellectual property. In an increasingly globalized world in which infectious disease pathogens travel faster and wider than before, the development of vaccines, treatments and other forms of medical technology has become an integral part of public health preparedness and response frameworks. The development of these technologies, and to a certain extent the allocation and distribution of resulting outputs, is informed by intellectual property regimes. These regimes influence the commitment of R&D resources, shape scientific collaborations and, in some cases, may condition the widespread availability of emerging technologies. As seen throughout this chapter, …

Ua19/16/2 Golf Press Releases, Wku Athletic Media Relations

WKU Archives Records

Press releases, photos and game statistics for WKU golf teams in 2021.

Ua19/16/2 Athletic Media Relations Press Releases, Wku Athletic Media Relations

WKU Archives Records

General WKU athletic press releases for 2021.

Ua19/16/2 Football Press Releases, Wku Athletic Media Relations

WKU Archives Records

Press releases, photos and statistics for WKU football team for 2021.

Ua19/16/2 Tennis Press Releases, Wku Athletic Media Relations

WKU Archives Records

Press releases, photos and game statistics for WKU tennis team in 2021.

Ua19/16/2 Track & Field Press Releases, Wku Athletic Media Relations

WKU Archives Records

Press releases, photos and meet statistics for WKU track & field team in 2021.

Ua19/16/2 Volleyball Press Releases, Wku Athletic Media Relations

WKU Archives Records

Press releases, photos and game statistics for WKU volleyball team in 2021.

Ua19/16/2 Baseball Press Releases, Wku Athletic Media Relations

WKU Archives Records

Press releases, photos and game statistics for WKU baseball team in 2021.

Nutritional Approach For Increasing Public Health During Pandemic Of Covid-19: A Comprehensive Review Of Antiviral Nutrients And Nutraceuticals, Vahideh Ebrahimzadeh-Attari, Ghodratollah Panahi, James R. Hébert Scd, Alireza Ostadrahimi, Maryam Saghafi-Asl, Neda Lotfi-Yaghin, Behzad Baradaran

Faculty Publications

Background: The novel coronavirus (COVID-19) is considered as the most life-threatening pandemic disease during the last decade. The individual nutritional status, though usually ignored in the management of COVID-19, plays a critical role in the immune function and pathogenesis of infection. Accordingly, the present review article aimed to report the effects of nutrients and nutraceuticals on respiratory viral infections including COVID-19, with a focus on their mechanisms of action.

Methods: Studies were identified via systematic searches of the databases including PubMed/ MEDLINE, ScienceDirect, Scopus, and Google Scholar from 2000 until April 2020, using keywords. All relevant clinical and experimental studies …

Meeting Minutes, Wku Council Of Academic Deans

Council of Academic Deans

Meeting regarding research compliance; graduate tuition fellowships; diversity, equity, inclusion initiatives; Chalk & Wire update; student success summit; living learning communities; strategic planning; COVID-19 vaccinations, 2021 course schedule; and academic standing.

Ua94/6/1 Covid-19 Diary, Daniel Myers

Student/Alumni Personal Papers

COVID-19 diary submitted to WKU Archives by student Daniel Myers for fall semester 2020.