Medicine and Health Sciences Commons^™

Functional Comt Val158met Polymorphism, Risk Of Acute Coronary Events And Serum Homocysteine: The Kuopio Ischaemic Heart Disease Risk Factor Study, Sari Voutilainen, Tomi-Pekka Tuomainen, Maarit Korhonen, Jaakko Mursu, Jyrki K. Virtanen, Pertti Happonen, Georg Alfthan, Iris Erlund, Kari E. North, M.J. Mosher, Jussi Kauhanen, Jari Tiihonen, George A. Kaplan, Jukka T. Salonen

Anthropology Faculty and Staff Publications

. The role of circulating levels of total homocysteine tHcy in the development of coronary heart disease (CHD) is still under debate. One reason for conflicting results between previous studies on homocysteine and heart diseases could be consequence of different interactions between homocysteine and genes in different study populations. Many genetic factors play a role in folate-homocysteine metabolism, like functional polymorphism (Val108Met) in the Catechol-O-methyltransferase (COMT) gene. Methodology and Findings. Our aim was to examine the role of COMT Val158Met polymorphism and interaction of this polymorphism with serum tHcy and folate concentration on the risk of acute coronary and events …