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Antioxidant Responses And Nrf2 In Synergistic Developmental Toxicity Of Pahs In Zebrafish, Alicia R. Timme-Laragy, Lindsey A. Van Tiem, Elwood A. Linney, Richard T. Di Giulio
Antioxidant Responses And Nrf2 In Synergistic Developmental Toxicity Of Pahs In Zebrafish, Alicia R. Timme-Laragy, Lindsey A. Van Tiem, Elwood A. Linney, Richard T. Di Giulio
Alicia R. Timme-Laragy
Early piscine life stages are sensitive to polycyclic aromatic hydrocarbon (PAH) exposure, which can cause pericardial effusion and craniofacial malformations. We previously reported that certain combinations of PAHs cause synergistic developmental toxicity, as observed with coexposure to the aryl hydrocarbon receptor agonist b-naphthoflavone (BNF) and cytochrome P4501A inhibitor a-naphthoflavone (ANF). Herein, we hypothesized that oxidative stress is a component of this toxicity. We examined induction of antioxidant genes in zebrafish embryos (Danio rerio) exposed to BNF or ANF individually, a BNF 1 ANF combination, and a prooxidant positive control, tert-butylhydroperoxide (tBOOH). We measured total glutathione (GSH) and attempted to modulate …