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Folate Deficiency, Hyperhomocysteinemia, Low Urinary Creatinine, And Hypomethylation Of Leukocyte Dna Are Risk Factors For Arsenic-Induced Skin Lesions, Richard Pilsner, Xinhua Liu, Habibul Ahsan, Vesna Ilievski, Vesna Slavkovich, Diane Levy, Pam Factor-Litvak, Joseph Graziano, Mary Gamble
Folate Deficiency, Hyperhomocysteinemia, Low Urinary Creatinine, And Hypomethylation Of Leukocyte Dna Are Risk Factors For Arsenic-Induced Skin Lesions, Richard Pilsner, Xinhua Liu, Habibul Ahsan, Vesna Ilievski, Vesna Slavkovich, Diane Levy, Pam Factor-Litvak, Joseph Graziano, Mary Gamble
J. Richard Pilsner
Background
Arsenic methylation relies on folate-dependent one-carbon metabolism and facilitates urinary As elimination. Clinical manifestations of As toxicity vary considerably among individuals and populations, and poor methylation capacity is thought to confer greater susceptibility.
Objective
After determining that folate deficiency, hyperhomocysteinemia, and low urinary creatinine are associated with reduced As methylation, and that As exposure is associated with increased genomic methylation of leukocyte DNA, we asked whether these factors are associated with As-induced skin lesion risk among Bangladeshi adults.
Methods
We conducted a nested case–control study of 274 cases who developed lesions 2 years after recruitment, and 274 controls matched …