Medicine and Health Sciences Commons^™

Influence Of Woodsmoke Exposure On Molecular Mechanisms Underlying Alzheimer’S Disease: Existing Literature And Gaps In Our Understanding, Adam Schuller, Luke Montrose

Public Health and Population Science Faculty Publications and Presentations

Woodsmoke poses a significant health risk as a growing component of ambient air pollution in the United States. While there is a long history of association between woodsmoke exposure and diseases of the respiratory, circulatory, and cardiovascular systems, recent evidence has linked woodsmoke exposure to cognitive dysfunction, including Alzheimer’s disease dementia. Alzheimer’s disease is a progressive neurodegenerative disorder with largely idiopathic origins and no known cure. Here, we explore the growing body of literature which relates woodsmoke-generated and ambient air pollution particulate matter exposure to Alzheimer’s disease (AD) onset or exacerbation, in the context of an inflammation-centric view of AD. …

Smoke From Wildfires Can Worsen Covid-19 Risk, Putting Firefighters In Even More Danger, Luke Montrose

Public Health and Population Science Faculty Publications and Presentations

Two forces of nature are colliding in the western United States, and wildland firefighters are caught in the middle.

Emerging research suggests that the smoke firefighters breathe on the front lines of wildfires is putting them at greater risk from the new coronavirus, with potentially lethal effects.

At the same time, firefighting conditions make precautions such as social distancing and hand-washing difficult, increasing the chance that, once the virus enters a fire camp, it could quickly spread.

As an environmental toxicologist, I have spent the last decade expanding our understanding of how wood smoke exposure impacts human health. Much of …

Neonatal Lead (Pb) Exposure And Dna Methylation Profiles In Dried Bloodspots, Luke Montrose

Public Health and Population Science Faculty Publications and Presentations

Lead (Pb) exposure remains a major concern in the United States (US) and around the world, even following the removal of Pb from gasoline and other products. Environmental Pb exposures from aging infrastructure and housing stock are of particular concern to pregnant women, children, and other vulnerable populations. Exposures during sensitive periods of development are known to influence epigenetic modifications which are thought to be one mechanism of the Developmental Origins of Health and Disease (DOHaD) paradigm. To gain insights into early life Pb exposure-induced health risks, we leveraged neonatal dried bloodspots in a cohort of children from Michigan, US …

What’S In Wildfire Smoke, And Why Is It So Bad For Your Lungs?, Luke Montrose

Public Health and Population Science Faculty Publications and Presentations

If I dare to give the coronavirus credit for anything, I would say it has made people more conscious of the air they breathe.

A friend texted me recently after going for a jog in the foothills near Boise, Idaho, writing: “My lungs are burning … explain what’s happening!!!”

A wildfire was burning to the east of town – one of hundreds of fires that were sending smoke and ash through communities in hot, dry western states. As an environmental toxicologist, I research how air pollution, particularly wood smoke, impacts human health and disease.