Medicine and Health Sciences Commons^™

Genotoxic Effects Of Synthetic Amorphous Silica Nanoparticles In The Mouse Lymphoma Assay, Esref Demir, Vincent Castranova

Faculty & Staff Scholarship

Synthetic amorphous silica nanoparticles (SAS NPs) have been used in various industries, such as plas-tics, glass, paints, electronics, synthetic rubber, in pharmaceutical drug tablets, and a as food additive in many processed foods. There are few studies in the literature on NPs using gene mutation approaches in mammalian cells, which represents an important gap for genotoxic risk estimations. To fill this gap, themouse lymphoma L5178Y/Tk+/−assay (MLA) was used to evaluate the mutagenic effect for five different concentrations (from 0.01 to 150 g/mL) of two different sizes of SAS NPs (7.172 and 7.652 nm) and a fine collodial form of silicon …