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Lyophilized Kit For The Preparation Of The Pet Perfusion Agent [68ga]-Maa, Alejandro Amor-Coarasa, Andrew Milera, Denny Carvajal, Seza Gulec, Anthony J. Mcgoron

Department of Biomedical Engineering Faculty Publications

Rapid developments in the field of medical imaging have opened new avenues for the use of positron emitting labeled microparticles. The radioisotope used in our research was 68Ga, which is easy to obtain from a generator and has good nuclear properties for PET imaging. Methods. Commercially available macroaggregated albumin (MAA) microparticles were suspended in sterile saline, centrifuged to remove the free albumin and stannous chloride, relyophilized, and stored for later labeling with 68Ga. Labeling was performed at different temperatures and times. 68Ga purification settings were also tested and optimized. Labeling yield and purity of relyophilized MAA microparticles were compared with …