Medicine and Health Sciences Commons^™

In Silico Modelling And Docking Simulation Of Egfr-Targeted Diphtheria Toxin Chimera With Various Targeting Moieties, Muhammad Afif Naufal Bmed, Benedictus Ansell Susanto Bmed, Talitha Dinda Gunawan Bmed, Azhar Ridha Lukman Bmed, Alifa Rahma Rizqina Bmed, Muhammad Misbahul Fuad Bmed

Indonesian Journal of Medical Chemistry and Bioinformatics

Introduction: Cancer is a major etiology of death worldwide due to high mortality and suboptimal medicine. However, an emerging field, targeted therapy enabled a more selective and effective therapeutic action. This article aims to analyze in-silico the hypothetical targeted therapy agent that is combinations of conjugate consisting of EGFR targeting moieties and diphtheria toxin (DT-390).

Method: Our novel peptide is a conjugate of a novel EGFR targeting peptide and DT-390, forming a chimera. The tertiary structure was predicted using AlphaFold 2.0. The best IDDT scoring and stereochemistry profiles were utilized. The HADDOCK2.4 webserver modelled the docking between our …

Heliport Emergency Medical Services (Hems) In Unstable Geopolitical Region; Palestine – Mobility Perspective, Anas Dirawi, Khaled A. Al-Sahili

Palestinian Medical and Pharmaceutical Journal

Currently, emergency medical services (EMS) in Palestine are solely provided through ground transportation. This study aims to explore the potential for implementing the most effective Heliport Emergency Medical Services (HEMS) system in Palestine and evaluate its expected performance. The current average demand for ground EMS stands at 83,000 trips per year, with many rural communities experiencing response times exceeding 25 minutes, which is considered high. The study investigates the most suitable locations for HEMS based on the condition of existing hospitals and aims to achieve the highest population coverage within the shortest possible response time. To determine these locations, the …

The Prospect Of Indonesian Herbal As An Alternative Treatment For Covid-19 Patient: A Literature-Based Study, Hadi Sunaryo, Wahyu Hidayati

Indonesian Journal of Medical Chemistry and Bioinformatics

Coronavirus disease 2019 (COVID-19) is a new disease caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease has several symptoms from mild to severe and could lead to death for comorbidities and the elderly. Therefore, the infections and mortality cases keep growing day by day, moreover many authorities are trying to suppress it by applying several health protocols, including medicines. Several studies were conducted on drug discovery from plants to cure the disease. The article aimed to do a narrative review about the prospect of JAMU becoming an alternative medicine to cure COVID-19 by mapping …

Metabolite Biomarker Discovery For Lung Cancer Using Machine Learning, Ariski Fajarido, Linda Erlina, Aryo Tedjo, Fadilah Fadilah, Wawaimuli Arozal

Indonesian Journal of Medical Chemistry and Bioinformatics

Lung cancer is the leading cause of cancer death worldwide. About 2.1 million lung cancer patients were diagnosed in 2018, accounting for about 11.6% of all newly diagnosed cancer cases. For lung cancer, blood is the first choice as a source of screening biomarker candidates. Blood biomarkers provide a snapshot of the patient's entire body, including the primary tumor, metastatic disease, immune response, and peritumoral stroma. However, sputum sampling, bronchial lavage or aspiration, exhaled breath (EB), and airway epithelial sampling represent unique samples for lung cancer and other airway cancers as potential sources for alternative biomarkers. Metabolites are products of …

In-House Polydimethylsiloxane Microfluidic Device On Single Cell Trapping And Culturing Of Leukemia Cell Line: Comparison Between Conventional And Conventional With Centrifugal Methods, Alongkorn Pimpin, Sudchaya Bhanpattanakul, Tepparit Wongpakham, Chomkwan Tawatcharaporn, Thanawit Siha-Umphai, Mookdapa Sinsiriphan, Atikan Chalermchuang, Tewan Tongmanee, Attawut Thanomsridetchai, Thammawit Suwannaphan, Witsaroot Sripumkhaie, Pattaraluck Pattamang, Mayuree Chanasakulniyom, Praprudee Piyaviriyakul, Wutthinun Jeamsaksiri, Achariya Sailasuta, Theerawat Tharasanit, Theerayuth Kaewamatawong

The Thai Journal of Veterinary Medicine

To develop a suitable model to study biological and characterization of Cancer stem cells (CSCs), single cell trapping and culturing using microfluidic techniques have become a high-through put system that can manage and control microenvironment and practical intracellular analysis. The aim of this study was to develop and validate a microfluidic device for single cell trapping and culturing using the leukemia cell line as a cell model. Comparison between conventional and conventional with centrifugal methods was also analyzed. To compare trapping efficacy between these 2 methods, leukemia cell concentration of 1.5×106 cells/ml was loaded with a flow rate of 0.25 …

The Bioremediation Effect Of Microalgae On Wastewater: A Green Technology Approach, Mohamed Ahmed Reda Hamed Dr, Marwa Abdelfattah Abdallah Dr

Journal of Engineering Research

The present study lays an emphasis on the microalgae-based for simultaneous wastewater bioremediation using Chlorella vulgaris and Micrococcus luteus mixed algal cultures to remove its constituent pollutants, amazing green technology guarantees benefits with the decrease in the formation of dangerous solid sludge. Ten days of fully monitoring laboratory experimental program were performed in batch cultures to investigate the effect of various dominant mixing ratios for attaining wastewater concentrations and different governing temperature ranges on the performance of microalgae treatment. The results revealed that there is a significant impact of both wastewater concentrations and temperature treatment conditions on the capability of …

Indicators And Evidence Of Environmental Sustainability For Pedestrian In Public Parks (Towards An Approach For Formulating A Guideline Evaluation Model), Nashwa Youssif

Journal of Engineering Research

يتناول البحث أحد المجالات التي فرضت تواجدها في الأونة الأخيرة علي الساحة العلمية والبحثية التي تتعلق بالعلاقة التبادلية التأثير بين الإنسان والفراغ العمراني حيث يتنامي الإهتمام بالخصائص الإنسانيه و مدي توافقها مع هذا الفراغ العمراني.

وتعد مسارات المشاة من أهم الحيزات العمرانية التى تشكل النسيج العمراني وأحد أهم وسائل التواصل الإجتماعي والثقافي والوظيفي نظرآ لإرتباطها بالغالبية العظمي من أفراد المجتمع، ومساعدتها على جذب العديـد من الأنشطة داخل الحدائق العامة. مما يشير إلي ضرورة الإهتمام بتحسين بيئة حركة المشاه كمدخل للتواصل والإستدامة.

ومن هنا تتمثل مشكلة البحث في نقص الدراسات حول تقييم العلاقة بين معايير الاستدامة التصميمية والنظم البيئية لمسارات المشاة …

Empirical Algorithms For Estimating Downwelling Light Attenuation At Λ=490 Nm From Sentinel-2 In A Narrow Optically Complex Bay, Plymouth Sound, United Kingdom, Louis J. Thornton

The Plymouth Student Scientist

This study investigates the potential of reflectance band ratios, modelled on Sentinel-2’s MultiSpectral Instrument (MSI) bands 10m resolution to estimate the downwelling attenuation coefficient for planar irradiance, Kd(λ), at 490nm (Kd(490)) in Plymouth Sound. Kd(λ) is vital for characterising subsurface light climate, strongly influencing physical and biogeochemical processes in coastal and oceanic waters. In temperate shelf seas, human activities have led to loss in vitality and spatial extent of structurally complex seabed, emphasizing the need for enhanced monitoring. Satellite-based remote sensing (RS) offers spatial and temporal advantages to conventional in situ methods. There are, however two main inadequacies that persist …

More Resilience, More Green Berets: A Quantitative Analysis Of The Effects Of Functional Imagery Training During British Army Commando Training, Emma S. J. Yates

The Plymouth Student Scientist

This study investigates the low completion rates of the British Army commando training course in 2018-2019, recorded at 20%, following concerns raised by course Directing Staff. It examines the relationship between resilience and performance in military contexts and evaluates whether resilience-building interventions can improve completion rates. To establish how completion rates could be improved, sixty-two candidates from three commando training cohorts were recruited and assigned to either a Functional Imagery Training (FIT) intervention or a control group. Interventions were delivered in week one of training with a booster in week five. FIT, a goal-centred imagery intervention, has previously improved resilience-related …

The Wellbeing Benefits Of Exposure To Nature: The Difference Between Environment Types On Different Wellbeing Types, Lily-Mae Petherick

The Plymouth Student Scientist

The world is facing a mental health crisis, thus implementing measures to improve wellbeing is a global priority. One way of combating this worldwide issue is through the well-known wellbeing benefits of nature. However, natural environments include more than just the well-known green spaces, and wellbeing encompasses multiple components. Consequently, this study compares the wellbeing outcomes of virtual exposure to a green space, blue space, and urban environment on both hedonic (pleasure) and eudaimonic wellbeing (meaningfulness). A factorial design was employed in which 96 University of Plymouth students watched one stressor video and then one of three environment videos (green, …

Employing Interactive Architecture Techniques In Architectural Design Methodologies To Retrieve Ancient Egyptian Identity, Dina Elwy Aly Hamed Hussein Dr. Lobna Abd-Allah Abd-Elfattah Agha , Dr. Azza Sobhi Ragab Elsakka

Journal of Engineering Research

Architectural projects often rely on modern technologies like smart architecture and environmental treatments, neglecting the principles and philosophy that reflect civilization, ideas, culture, and traditions. This leads to short-lived buildings that depend on these technologies without any purpose of preserving them. Technicians must constantly renew technology to improve production and without benefits, as threats of superior artificial intelligence have been warned, that autonomous machines may perform tasks without programmers understanding how to reach this level. Instead of relying solely on environmental or smart technology, we should make technology serve the design idea rather than relying solely on it. Considering this, …

The Effect Of Lighting In Color In The Interior Space Of The Residential Unit, Abd Elbary Eldininy Abd Elbary Eldininy

Journal of Engineering Research

ABSTRACT: Humanity is spending more and more time indoors, both at work and at home - with studies showing that we now spend 87% of our lives indoors. Residential environ ments both positively affect the mood and well-being of its occupants, just as places with poor and uncomfortable lighting and colors can make life miserable. This is why we are interested in this issue. The importance of knowing the issues of lighting and colors in order to obtain a well thought-out interior design. The interior designer has the ability to control in the quality of lighting of various types, artificial …

Green Facade Strategy To Mitigate Heat Islands, Arch. Aya Gamal Abdel Hamid Muhammad Prof. Mai Wahba Madkour... Dr. Rania Elghamry Ashmawy Tolba Elakab

Journal of Engineering Research

In the beginning of the twentieth century and the occurrence of the economic crisis that accompanied by a climate crisis, that one of its indicators the rise in temperatures and the formation of hot zones, especially in crowded cities, including Cairo in particular, as it is considered one of the crowded cities in the world, and this noticeable rise in temperatures in Some areas where hot zones form are called heat islands. This results because of the nature of the urban environment, which has a high building density, little natural landscape, and human and industrial activities that has a negative …

Light Structure Building Technology Towards Sustainable Environmental Design, Sally El-Sayed Prof. Dr. Mai Wahba Madkour2, Prof. Dr. Marwa Ahmed Kamer El-Dawla3

Journal of Engineering Research

The building and construction industry is one of the most important sectors globally , as it plays a vital role in providing housing and infrastructure that meets the needs of various communities , However , this industry is considered one of the largest contributors of negative environmental impacts in terms of consuming huge amounts of natural resources in an unsustainable manner and a subsequent increase in energy consumption .Therefore, it was necessary to find solutions and explore for new and sustainable construction methods to alleviate these problems .This research paper will focus on the use of light buildings and their …

Available Building Technology As A Tool For Developing Construction And Structure Systems., J. Q. . Nader Ibrahim Ismael

Journal of Engineering Research

The research aims to study the impact of available building technology in each era in the development of the constructional thought and implementation techniques used and its impact on the development of different types of buildings, through the emergence of different types of buildings and the development of buildings types in terms of shape and height, through the development of building materials used Whether construction materials or finishing materials, as well as used construction techniques and equipment, and the impact of all on the development of construction thought and construction systems through different eras . The research also represents an …

Increasing Occupancy Rates In Coastal Tourism Development At The Regional Level In Support Of A Sustainable Quality Of Life In Egypt, عبدالرحمن محمد عبدالقادر موسي

Journal of Engineering Research

إن استغلال الفراغات التي تمثل أكثر من 80% من مساحة المنتجعات السياحية الساحلية في الأنشطة الرياضية والترفيهية والثقافية والاجتماعية وتوفير الخدمات المختلفة عن طريق دعم الخدمات الإلكترونية التي تساعد الزائرين في قضاء وقت أكبر بتلك القري السياحية، مع تعلم السباحة وركوب الدرجات والتجديف والتسلق وركوب الخيل دعما لجودة الحياة ، حيث التمتع بالهواء المتجدد القادم من البحر بعيدا عن التلوث والضوضاء، ولزيادة الاستفادة والدعم يتم توفير وحدات فندقة لغير الملاك لزيادة الزوار والاتفاق مع المدارس والجامعات لتنشيط تلك الرحلات للشواطئ وممارسة الأنشطة المميزة لهؤلاء الشباب والاستفادة من الخدمات الجيدة والفراغات الصحية والهواء المتجدد وتعلم الرياضات الشاطئية المفيدة وذلك الاتجاه من …

Enhancing Daylight Using Sustainable Natural Lighting Techniques In Modern Architecture, سارة حسني شعلان أ.م.د/ لبني عبد الفتاح أغا

Journal of Engineering Research

Natural lighting is one of the basic criteria for the architectural design process. It is one of the most important data that contributes to the design of architectural spaces and the manifestation of aesthetic values. In light of the global technological development and the scientific and information revolution, the role of the architect comes in highlighting the importance of natural lighting and its positive role in human biology, and reducing effort and psychological pressure in the event of Its use is an alternative to artificial lighting, as it increases human efficiency and achievement at work, in addition to giving a …

Green Architecture Strategies To Achieve Sustainability In Buildings, Azza Sobhi Ragab Elsakka J. Q. Assos., Menna Ashraf Saeid Ali

Journal of Engineering Research

في الوقت الحالي توجد حاجة مُلحة لتطبيق معايير الاستدامة التي تعني المحافظة على الموارد الحالية و استخدامها بحيث لا تقل استفادة الأجيال القادمة من تلك الموارد ، و للاستدامة عدة جوانب لتطبيقها أحد تلك التطبيقات هي العمارة الخضراء ، العمارة الخضراء مرت بعدة مراحل بدءاً من القرن السابع عشر ( منذ العصر العثماني الاسلامي ) من خلال وجود بعض الأساليب الغير مباشرة في التصميم التي توفر التهوية و الإضاءة الطبيعية و حتى عصرنا هذا، حيث وُجد تقييم لأداء المبنى الأخضر من حيث أسلوب التصميم و الإنشاء بحيث لا يؤثر على البيئة تأثير سلبي و ما زال التطوير مستمر في إنشاء …

The Impact Of Green Infrastructure On Urban Heat Island Phenomenon In Existing Cities, Neveen Youssef Azmy Basant Elsayed Abu-Farrag, Walaa Abou El-Haggag Mehanna

Journal of Engineering Research

Rapid urbanization and overpopulation, along with a lack of green space, led to an increase in air temperature, lowering the rate of thermal comfort in dense urban areas, decreasing air quality, and increasing the urban heat island (UHI) phenomenon, particularly in existing cities. As a result, the research aims to reduce the UHI effect and improve the thermal performance of existing Egyptian cities by adopting green infrastructure (GI) principles and demonstrating their effectiveness on the UHI phenomenon. This research concentrates on the UHI phenomenon as one of the environmental issues facing urbanization and includes a review of green infrastructure (GI) …

Optimizing Fenestration Systems In Residential Buildings: A Parametric Analysis Of Egyptian Energy Codes' Impact On Thermal Comfort, Wafik El-Menshawi Ali F. Bakr , Amira A.Fathi

Journal of Engineering Research

- Fenestration systems, such as windows, doors, and skylights, play a crucial role in improving thermal comfort and reducing energy consumption in buildings. In Egypt, the energy code establishes standards for fenestration systems to promote energy efficiency and carbon emission reduction. Residential buildings account for a significant portion of total energy consumption, making the optimization of fenestration systems essential. This research focuses on studying the optimization of fenestration systems in Egyptian residential buildings through parametric analysis, considering energy standards and their impact on total energy gain and thermal comfort. The paper examines existing energy codes for fenestration systems and explores …

Towards Green Cities As An Approach To Achieve Climate Change Adaptation, Noha H. Hefnawy Nouran M. Ibrahim

Journal of Engineering Research

Climate change is a complicated problem and there is an urgent need for climate change adaptation. Cities are the primary drivers of social, economic, and technical progress. Green Cities are cities that show high environmental performance relative to adapting risks derived from climate change while maximizing the economic and social co-benefits. The Authors adopted a data collection strategy to review the issues, and difficulties caused by climate change and how green cities could assist in addressing them, then adopted a case study analysis to analyze the strategies used by Sharm El Sheikh in the transition to green city. The study …

Using Recycled Materials Towards Sustainable, Eco-Friendly Building In Hot Regions – A Review, Mai W. Madkour Hosny A. Dewer, And Shaimaa M. Refaat

Journal of Engineering Research

Due to population growth and increased urban activity, there is a rise in waste production, which poses health and environmental risks. Additionally, the extraction and transportation of natural resources to places of employment require significant energy consumption, and the world has therefore moved to seek new alternatives away from traditional construction methods by recycling building materials such as concrete, brick, glass, wood, etc., or using new building materials such as rice straw, plastics, corks, etc., taking into account architectural design. The research is aimed at demonstrating that recycled materials have the potential to perform a better environmental performance by preserving …

Sustainable Design Of Open Service Spaces In Universities (The American University In Cairo As An Example), مصطفى منصور عبد المجي أ.م.د. زينب لطفى عبدالحكيم خليفة

Journal of Engineering Research

إن الجامعات المستدامة تعد اتجاهاً مستقبلياً معاصراً لابد أن تحرص مؤسسات التعليم العالي على تبني مبادئه، ووضع خارطة طريق مستقبلية، وتتطلب استدامة الجامعات مواجهة الكثير من التحديات الجغرافية لضمان توفير بيئة آمنه ومريحة مع الحد الأدنى من الهدر، وإيلاء اهتمام خاص لاحتياجات الطلاب وجميع العاملين بالجامعة، والقدرة على تخطيط وإدارة الحيزات الخدمية المفتوحة بها وإقامة المنشآت المستدامة.

Agile Vs Waterfall As An Approach For Effective Management Practices In Fit Out Projects (Preferences Of Project Managers), Moutaz M. El Baz 1

Journal of Engineering Research

Optimum time, cost & quality are the key objectives in managing fit-out projects. Waterfall and Agile are the most common approaches for achieving the project objectives. To determine the optimal managerial approach for fit-out projects, it was essential to study the project life cycle & phases, waterfall & agile methodologies & phases and the project management performance indicators. To achieve the research goals, a data gathering/analysis performed among three steps. Firstly, by performing qualitative research through semi-structured interviews with project management experts to verify the research hypothesis. Secondly, through studying the project & project management life cycle, phases and characteristics …

Improving Home Designs For Disease Prevention In Gated Communities And Satisfying Living Space Needs In Egypt: A Post-Pandemic Living Assessment, A. Moustafa Kamel Neveen Youssef Azmy, Shahira Sharaf Eldin

Journal of Engineering Research

Abstract Pandemics such as SARS and COVID-19 have highlighted the importance of preventing and controlling diseases. Virus transmission in residential buildings, especially multi-unit apartment complexes, has prompted calls for innovative housing designs. While Western countries prioritize physical and mental health in residential building design, China focuses on comfort, aesthetics, appearance, and lifestyle.

Studying The Problems Of Delayed Receipt Of University Buildings In Egypt During The Corona Pandemic, أ.د / مروه قمر الدولة أ.د / لبنى أغا

Journal of Engineering Research

على الرغم من وجود العديد من الدراسات السابقة في مجال تأخير مشاريع البناء. إلا أن هناك أبحاث محدودة جدًا تتناول تأثير كورونا على عوامل تأخر مشاريع البناء. وعليه فإن هذا البحث يتناول آراء المتخصصين حول تأثير جائحة كورونا على العوامل المسببة للتأخير في عملية البناء في مصر. ومن المتوقع أن تساهم نتائج هذا البحث في دراسة العوامل المسببة لهذا التأخير ومحاولة تقديم بعض التوصيات التي تساهم في وضع الخطط المستقبلية لمواجهة الظروف الاستثنائية المماثلة، يهدف هذا البحث إلى قياس أهمية العوامل المسببة للتأخير في عمليات البناء في مصر على مستوى المباني الجامعية بعد جائحة كورونا، وللوصول الى ذلك الهدف اتخذت …

Design Characteristics Of The External Envelope Of Modern High-Rise Buildings In Egypt: Concepts And Indicators Of Energy Performance, حازم عز الدين قاسم ، نوبى محمد حسن، مصطفى محمد سيد

Journal of Engineering Research

إعتمدت الدولة المصرية فى الآونة الأخيرة نمط المبانى العالية فى مخططاتها لمراكز مدن الجيل الرابع الجديدة الجارى إنشاؤها فى العديد من المناطق، وذلك فى إطار سعى الدولة لتغيير الخريطة العمرانية والتوسع في الإستثمار العقاري وخلق مجتمعات مواكبة للتطور العمراني والتكنولوجي بما يتوافق مع رؤية مصر٢٠٣٠، ومع البدء فى ظهور وإعتماد العشرات من مشروعات المبانى العالية فى مصر، أصبح من الضرورى دراسة تصميم الغلاف الخارجى لتلك المبانى ومدى ملاءمته للمناخ والبيئة المحلية، وذلك بهدف الوصول لأفضل أداء للطاقة وأعلى كفاءة للإستهلاك.

The Design Of The Outer Casing Is Compatible With The Hot Climate Environment, حازم عز الدين قاسم نوبى محمد حسن مصطفى محمد سيد

Journal of Engineering Research

تعتبر المبانى العالية أحد أقل أنماط المبانى توافقاً مع البيئة والمناخ، وذلك بسبب إنعزالها عن النسيج العمرانى المحيط وتعرضها للعديد من العوامل المناخية بشكل أكبر من المبانى المنخفضة، لذا يعتبر الغلاف الخارجى هو العنصر الأهم فى تصميم المبنى العالي لكونه بمثابة الجدار الفاصل بين البيئة الخارجية ذات الظروف المناخية القاسية وبين البيئة الداخلية التى يجب الوصول فيها لراحة المستخدم الحرارية، حيث يعد الغلاف الخارجى هو المسئول عن ما يقرب من 60% من إجمالى الطاقة التى يستهلكها المبنى العالى وذلك فى أعمال التبريد والتهوية الصناعية [1].

An Analytical Study Of Key Performance Indicators For Knowledge Management In Construction Companies, Marwa. M. Ahmed Ayman A.E. Othman, Essam Eldin. K. Mahrous

Journal of Engineering Research

The construction and building industry plays a pivotal role in both national and global economies, necessitating a focused approach in knowledge management (KM) strategies amid current market disruptions and economic uncertainties. For construction companies to plan and develop effective KM strategies, they must be measured and incorporated within the key performance indicators (KPIs) relevant to construction companies. This research paper aims to review literature on knowledge management performance indicators (KM PIs) and rank their importance within the KPIs of contracting companies. Statistical analysis revealed that previous studies neglect KM PIs, such as, as some important techniques for KM, such as …

Heritage Preservation In Egyptian Villages And Centers, Azza Elsakka Ahmed Abdalwahaab , Ebtehal Fady Shareef

Journal of Engineering Research

Heritage holds deep significance as a collective memory and a source of pride for any society. However, in today's world, it has evolved beyond its symbolic status and emerged as a crucial factor in human development across various dimensions. Preserving and restoring heritage has thus become an urgent issue that demands extensive cooperation between governments, international society, and community associations.