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Full-Text Articles in Medicine and Health Sciences
Integrating Galectin-3 Into A Computational Model Of Cardiac Fibrosis Progression, Adam Pieratt
Integrating Galectin-3 Into A Computational Model Of Cardiac Fibrosis Progression, Adam Pieratt
Chemical Engineering Undergraduate Honors Theses
Cardiac fibrosis, a large contributor to heart failure, is the excessive accumulation of extracellular matrix in response to stress or injury. There are no approved treatments for cardiac fibrosis, and targeting specific species involved creates complex problems for drug development, so a computational model of the cardiac fibroblast signaling network can be used to observe the interactions involved in the progression of cardiac fibrosis. In this paper, a new protein called galectin-3 is integrated into this existing model, and connections are established to expand the coverage of the network. The additions are described, simulated using Netflux biological system simulation software, …
Simulating Alternative Tuberculosis Diagnosis Methods In Underdeveloped Countries, Luke Turner
Simulating Alternative Tuberculosis Diagnosis Methods In Underdeveloped Countries, Luke Turner
Industrial Engineering Undergraduate Honors Theses
Tuberculosis is the deadliest infectious disease in the world; it is especially rampant in underdeveloped countries because they do not have the infrastructure, technology, or funding to properly combat the infection. However, the development of portable point-of-care diagnosis machines can reverse this epidemic as they far surpass conventional laboratory identification. The question now is where to place these machines, which is a difficult decision with a lack of data. Therefore, a flexible simulation model is created to test the implementation of these machines with different countries and configurations. The simulation tests the baseline model and three proposed implementations of the …
Dispensing Medical Countermeasures In Public Health Emergencies Via Home Health Agencies And Points Of Distribution, Anna Hudgeons
Dispensing Medical Countermeasures In Public Health Emergencies Via Home Health Agencies And Points Of Distribution, Anna Hudgeons
Industrial Engineering Undergraduate Honors Theses
A major concern regarding emergency preparedness on the state government level involves the handling and dispensing of the Strategic National Stockpile (SNS) of medicinal supplies. Each state is required to update and maintain a plan of action for dispensing SNS materials that would effectively provide care to the state’s population in times of distress. This research evaluates a state’s ability to dispense an adequate amount of medicine to her population in a timely manner, specifically after it has been received by the state government. Although simulation modeling has previously been utilized to replicate the dispensing process at pre-designated points of …