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Antibodies;; cytokines;; herbal component;; HMGB1;; innate immune cells;; PKR;; sepsis;; MOBILITY GROUP BOX-1;; HMGB1-INDUCED INFLAMMATORY RESPONSES;; INDUCED;; SEPTIC MICE;; CHROMATIN PROTEIN HMGB1;; TOLL-LIKE RECEPTORS;; CLP-INDUCED;; SEPSIS;; ACUTE LUNG INJURY;; LETHAL SEPSIS;; INHIBITS HMGB1;; IN-VIVO;; Pharmacology & Pharmacy
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Full-Text Articles in Medicine and Health Sciences
Targeting Hmgb1 In The Treatment Of Sepsis, H. C. Wang, M. F. Ward, A. E. Sama
Targeting Hmgb1 In The Treatment Of Sepsis, H. C. Wang, M. F. Ward, A. E. Sama
Journal Articles
Introduction: Sepsis refers to the host's deleterious and non-resolving systemic inflammatory response to microbial infections and represents the leading cause of death in the intensive care unit. The pathogenesis of sepsis is complex, but partly mediated by a newly identified alarmin molecule, the high mobility group box 1 (HMGB1). Areas covered: Here we review the evidence that support extracellular HMGB1 as a late mediator of experimental sepsis with a wider therapeutic window and discuss the therapeutic potential of HMGB1-neutralizing antibodies and small molecule inhibitors (herbal components) in experimental sepsis. Expert opinion: It will be important to evaluate the efficacy of …