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Full-Text Articles in Medicine and Health Sciences
Long-Term Correction Of Ornithine Transcarbamylase Deficiency By Wpre-Mediated Overexpression Using A Helper-Dependent Adenovirus, Asad Mian, W. Michael Mccormack Jr, Viraj Mane, Soledad Kleppe, Philip Ng, Milton Finegold, William E. O'Brien, John R. Rodgers, Arthur L. Beaude, Brendan Lee
Long-Term Correction Of Ornithine Transcarbamylase Deficiency By Wpre-Mediated Overexpression Using A Helper-Dependent Adenovirus, Asad Mian, W. Michael Mccormack Jr, Viraj Mane, Soledad Kleppe, Philip Ng, Milton Finegold, William E. O'Brien, John R. Rodgers, Arthur L. Beaude, Brendan Lee
Department of Emergency Medicine
The urea cycle disorders (UCDs) are important models for developing gene replacement therapy for liver diseases. Long-term correction of the most common UCD, ornithine transcarbamylase (OTC) deficiency, has yet to be achieved in clinical or preclinical settings. The single human clinical trial using early-generation adenovirus (Ad) failed to show any biochemical correction. In adult OTC-deficient mice, an E1/E2-deleted Ad vector expressing the mouse OTC gene, but not the human, was only transiently therapeutic. By using post-transcriptional overexpression in the context of the less immunogenic helper-dependent adenoviral vector, we achieved metabolic correction of adult OTC-deficient mice for >6 months. Demonstrating this …
Emergency Medicine: A Relatively New Specialty, Rifat Rehmani
Emergency Medicine: A Relatively New Specialty, Rifat Rehmani
Department of Emergency Medicine
No abstract provided.
Orbital Cellulitis Masquerading As Cavernous Sinus Thrombosis: A Case Report, M. R. Shaikh, Syed Muhammad Baqir, N. Zakir
Orbital Cellulitis Masquerading As Cavernous Sinus Thrombosis: A Case Report, M. R. Shaikh, Syed Muhammad Baqir, N. Zakir
Department of Emergency Medicine
No abstract provided.
Emergency Section And Overcrowding In A University Hospital Of Karachi, Pakistan, R Rehmani
Emergency Section And Overcrowding In A University Hospital Of Karachi, Pakistan, R Rehmani
Department of Emergency Medicine
Objective: To quantify the extent of Emergency Section overcrowding at a tertiary care hospital and to identify possible solutions.Methods: This was a retrospective chart review of all the patients presented to the Aga Khan University Hospital's (AKUH) Emergency Section (ES). The ES information system has an automatic patient log and generates daily report for patients who stay longer than 6 hours. The charts of all patients who stayed longer than 6 hours were reviewed.Results: Among 9630 patients, 1999 (20.8%) were held in the ES for more than 6 hours. Of those 134 (6.7%) were discharged from the ES, while 1535 …