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- Amondys 45 (1)
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- Casimersen (1)
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- Publication
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- Research outputs 2022 to 2026 (5)
- Digital Journal of Clinical Medicine (2)
- All Faculty Scholarship for the College of Education and Professional Studies (1)
- DNP Research Projects (1)
- Department of Exercise Science Faculty Papers (1)
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- Department of Pediatrics Faculty Papers (1)
- Dissertations (1)
- Electronic Thesis and Dissertation Repository (1)
- Indian Journal of Research in Homoeopathy (1)
- Internet Journal of Allied Health Sciences and Practice (1)
- Mako: NSU Undergraduate Student Journal (1)
- School of Medicine Faculty Publications (1)
- Student Papers, Posters & Projects (1)
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Articles 1 - 19 of 19
Full-Text Articles in Medicine and Health Sciences
Amondys 45 (Casimersen), A Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations For Treatment In Duchenne Muscular Dystrophy, Megan E. Vasterling, Rebecca J. Maitski, Brice A. Davis, Julie E. Barnes, Rucha A. Kelkar, Rachel J. Klapper, Hirni Patel, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye, Giustino Varrassi
Amondys 45 (Casimersen), A Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations For Treatment In Duchenne Muscular Dystrophy, Megan E. Vasterling, Rebecca J. Maitski, Brice A. Davis, Julie E. Barnes, Rucha A. Kelkar, Rachel J. Klapper, Hirni Patel, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye, Giustino Varrassi
School of Medicine Faculty Publications
AMONDYS 45 (casimersen) is an antisense oligonucleotide therapy used to treat Duchenne muscular dystrophy (DMD), a rare genetic disorder characterized by a mutation in the DMD gene. Symptoms include progressive muscle weakness, respiratory and cardiac complications, and premature death. Casimersen targets a specific mutation in the DMD gene that results in the absence of dystrophin protein, a key structural component of muscle fibers. While there is currently no cure for DMD, exon-skipping therapy works by restoring the reading frame of the mutated gene, allowing the production of a partially functional dystrophin protein. Clinical trials of casimersen have shown promising results …
Human Parechovirus Central Nervous System Infection In A Young Infant Cohort, Aspasia Katragkou, Avni Sheth, Christina Gagliardo, Jessica Aquino, Niva Shah, Eberechi Nwaobasi-Iwuh, Christina Melchionne, Paige Black, Stephanie Chiu, Cecilia Di Pentima
Human Parechovirus Central Nervous System Infection In A Young Infant Cohort, Aspasia Katragkou, Avni Sheth, Christina Gagliardo, Jessica Aquino, Niva Shah, Eberechi Nwaobasi-Iwuh, Christina Melchionne, Paige Black, Stephanie Chiu, Cecilia Di Pentima
Department of Pediatrics Faculty Papers
In 2022, a surge in cases of pediatric human parechovirus (HPeV) central nervous system infections in young infants was seen at our institution. Despite the dramatic increase in the number of cases seen that year, the clinical features of the illness were similar to prior years. The recent pediatric HPeV surge highlights the need to evaluate treatment options and standardize follow-up to better understand the long-term prognosis of infants with HPeV infection.
The Effects Of Herbal Products In Cartilage Healing And Reducing The Progression Of Osteoarthritis, Mariya Baig, Mir Saleem
The Effects Of Herbal Products In Cartilage Healing And Reducing The Progression Of Osteoarthritis, Mariya Baig, Mir Saleem
Mako: NSU Undergraduate Student Journal
Treatment for osteoarthritis (OA) includes symptom management with nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and acetaminophen. However, these drugs pose health risks for long-term use, such as contraindications and gastrointestinal/cardiovascular issues. This systematic review of the literature was conducted to evaluate the impact of the herbal products, turmeric and ginger, in cartilage healing and reducing the progression of OA. It was found that turmeric and ginger can aid in symptom management for OA and promote cartilage regeneration, with turmeric extract yielding greater evidence-based results. Turmeric reduces the amount of pain and stiffness experienced from OA and can restore cartilage by subduing …
Exploring The Experience Of Sexuality And Gender During The Healthcare Transition Of The Youth With Cerebral Palsy, Umma Salma
Electronic Thesis and Dissertation Repository
Background: Transition from the pediatric to adult health care system is an important phase of healthcare for youth with cerebral palsy (CP). Sexuality and gender are two very important components of health that are mostly ignored in the healthcare transition process. It is possible that health care providers only see a client’s disability, and therefore, key aspects of sexuality and gender diversity may be ignored, or deemed irrelevant as a result of their disability status. Therefore, the purpose of our study is to explore how gender and sexuality may influence the experience of health care transition for youth with cerebral …
Csf1r Regulates Schizophrenia-Related Stress Response And Vascular Association Of Microglia/Macrophages, Ling Yan, Yanli Li, Fengmei Fan, Mengzhuang Gou, Fangling Xuan, Wei Feng, Keerthana Chithanathan, Wei Li, Junchao Huang, Hongna Li, Wenjin Chen, Baopeng Tian, Zhiren Wang, Shuping Tan, Alexander Zharkovsky, L Elliot Hong, Yunlong Tan, Li Tian
Csf1r Regulates Schizophrenia-Related Stress Response And Vascular Association Of Microglia/Macrophages, Ling Yan, Yanli Li, Fengmei Fan, Mengzhuang Gou, Fangling Xuan, Wei Feng, Keerthana Chithanathan, Wei Li, Junchao Huang, Hongna Li, Wenjin Chen, Baopeng Tian, Zhiren Wang, Shuping Tan, Alexander Zharkovsky, L Elliot Hong, Yunlong Tan, Li Tian
Student and Faculty Publications
BACKGROUND: Microglia are known to regulate stress and anxiety in both humans and animal models. Psychosocial stress is the most common risk factor for the development of schizophrenia. However, how microglia/brain macrophages contribute to schizophrenia is not well established. We hypothesized that effector molecules expressed in microglia/macrophages were involved in schizophrenia via regulating stress susceptibility.
METHODS: We recruited a cohort of first episode schizophrenia (FES) patients (n = 51) and age- and sex-paired healthy controls (HCs) (n = 46) with evaluated stress perception. We performed blood RNA-sequencing (RNA-seq) and brain magnetic resonance imaging, and measured plasma level of colony stimulating …
Identification Of Potential Non-Invasive Biomarkers In Diastrophic Dysplasia, Chiara Paganini, Ricki S. Carroll, Chiara Gramegna Tota, Andrea J. Schelhaas, Alessandra Leone, Angela L. Duker, David A. O'Connell, Ryan F. Coghlan, Brian Johnstone, Carlos R. Ferreira, Sabrina Peressini, Riccardo Albertini, Antonella Forlino, Luisa Bonafé, Ana Belinda Campos-Xavier, Andrea Superti-Furga, Andreas Zankl, Antonio Rossi, Michael B. Bober
Identification Of Potential Non-Invasive Biomarkers In Diastrophic Dysplasia, Chiara Paganini, Ricki S. Carroll, Chiara Gramegna Tota, Andrea J. Schelhaas, Alessandra Leone, Angela L. Duker, David A. O'Connell, Ryan F. Coghlan, Brian Johnstone, Carlos R. Ferreira, Sabrina Peressini, Riccardo Albertini, Antonella Forlino, Luisa Bonafé, Ana Belinda Campos-Xavier, Andrea Superti-Furga, Andreas Zankl, Antonio Rossi, Michael B. Bober
Student Papers, Posters & Projects
Diastrophic dysplasia (DTD) is a recessive chondrodysplasia caused by pathogenic variants in the SLC26A2 gene encoding for a cell membrane sulfate/chloride antiporter crucial for sulfate uptake and glycosaminoglycan (GAG) sulfation. Research on a DTD animal model has suggested possible pharmacological treatment approaches. In view of future clinical trials, the identification of non-invasive biomarkers is crucial to assess the efficacy of treatments. Urinary GAG composition has been analyzed in several metabolic disorders including mucopolysaccharidoses. Moreover, the N-terminal fragment of collagen X, known as collagen X marker (CXM), is considered a real-time marker of endochondral ossification and growth velocity and was studied …
Implementation Of A Vestibular Disorder Screening Tool In An Urgent Care, Kathleen A. Probst
Implementation Of A Vestibular Disorder Screening Tool In An Urgent Care, Kathleen A. Probst
Dissertations
Implementation of a Vestibular Disorder Screening Tool in an Urgent Care
Kathleen A. Probst
M.S.N., University of Missouri-Columbia, 2007
B.S.N., University of Missouri-Columbia, 2004
A Dissertation Submitted to The Graduate School at the University of Missouri-St. Louis in partial fulfillment of the requirements for the degree
Doctor of Nursing Practice
August 2023
Advisory Committee
Susan Dean-Baar, PhD, RN, CENP, FAAN
Chairperson
Jennifer Vines, DNP, MSN, RN
Troy Dinkel, MD
Copyright, Kathleen A. Probst, 2023
Abstract
Problem: Vestibular disorders disrupt everyday living and can cause reduced quality of life. Guidelines developed to screen for vestibular disorders are not efficient to use …
Homoeopathy In Management Of Chronic Ischaemic Ulcer: An Evidence-Based Case Report, Jayabharathi Srinivasagam, Rohini S, Srinivas Govindarajulu, Tamil Selvi S
Homoeopathy In Management Of Chronic Ischaemic Ulcer: An Evidence-Based Case Report, Jayabharathi Srinivasagam, Rohini S, Srinivas Govindarajulu, Tamil Selvi S
Indian Journal of Research in Homoeopathy
Introduction: Ischaemic or arterial ulcer occurs when there is an obstruction in the arterial supply to a particular part of the human body leading to necrosis. These are extremely painful types of chronic wounds. Treating arterial ulcers is a difficult task for the physician since supportive measures such as compression therapy and leg elevation are contraindicated. Surgical intervention is the ultimate approach to manage in conventional medicine. The homoeopathic system of medicine offers a wide range of medicines and a holistic approach to treat such cases non-invasively. Case Summary: A case of a 75-year-old woman who suffered from chronic ischaemic …
Art Therapy As A Comprehensive Complementary Treatment For Parkinson’S Disease, Tom Ettinger, Marygrace Berberian, Ikuko Acosta, Alberto Cucca, Andrew Feigin, Danilo Genovese, Travis Pollen, Julianne Reiders, Rohita Kilachand, Clara Gomez, Milton Biagioni, Alessandro Di Rocco, Felice M. Ghilardi, John-Ross Rizzo
Art Therapy As A Comprehensive Complementary Treatment For Parkinson’S Disease, Tom Ettinger, Marygrace Berberian, Ikuko Acosta, Alberto Cucca, Andrew Feigin, Danilo Genovese, Travis Pollen, Julianne Reiders, Rohita Kilachand, Clara Gomez, Milton Biagioni, Alessandro Di Rocco, Felice M. Ghilardi, John-Ross Rizzo
Department of Exercise Science Faculty Papers
Introduction: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. Complementary and alternative therapies are increasingly utilized to address its complex multisystem symptomatology. Art therapy involves motoric action and visuospatial processing while promoting broad biopsychosocial wellness. The process involves hedonic absorption, which provides an escape from otherwise persistent and cumulative PD symptoms, refreshing internal resources. It involves the expression in nonverbal form of multilayered psychological and somatic phenomena; once these are externalized in a symbolic arts medium, they can be explored, understood, integrated, and reorganized through verbal dialogue, effecting relief and positive change.
Methods: 42 participants with mild to …
Reduced Peak Bone Mass In Young Adults With Low Motor Competence, Jocelyn Tan, Carrie Anne Ng, Nicolas H. Hart, Timo Rantalainen, Marc Sim, David Scott, Kun Zhu, Beth Hands, Paola Chivers
Reduced Peak Bone Mass In Young Adults With Low Motor Competence, Jocelyn Tan, Carrie Anne Ng, Nicolas H. Hart, Timo Rantalainen, Marc Sim, David Scott, Kun Zhu, Beth Hands, Paola Chivers
Research outputs 2022 to 2026
Although suboptimal bone health has been reported in children and adolescents with low motor competence (LMC), it is not known whether such deficits are present at the time of peak bone mass. We examined the impact of LMC on bone mineral density (BMD) in 1043 participants (484 females) from the Raine Cohort Study. Participants had motor competence assessed using the McCarron Assessment of Neuromuscular Development at 10, 14, and 17 years, and a whole-body dual-energy X-ray absorptiometry (DXA) scan at 20 years. Bone loading from physical activity was estimated from the International Physical Activity Questionnaire at the age of 17 …
Cardiovascular Disease, Muscle Function, And Long-Term Falls Risk: The Perth Longitudinal Study Of Ageing Women, Abadi K. Gebre, Marc Sim, Jack Dalla Via, Alexander J. Rodríguez, Kun Zhu, John T. Schousboe, Jonathan M. Hodgson, Catherine P. Bondonno, Richard L. Prince, Joshua R. Lewis
Cardiovascular Disease, Muscle Function, And Long-Term Falls Risk: The Perth Longitudinal Study Of Ageing Women, Abadi K. Gebre, Marc Sim, Jack Dalla Via, Alexander J. Rodríguez, Kun Zhu, John T. Schousboe, Jonathan M. Hodgson, Catherine P. Bondonno, Richard L. Prince, Joshua R. Lewis
Research outputs 2022 to 2026
Background: A few cross-sectional studies have highlighted inconsistent associations between cardiovascular disease (CVD) and musculoskeletal conditions. We sought to investigate the relationship between clinical CVD including subtypes, compromised muscle function, as well as incident self-reported and injurious falls in older women. Materials and methods: 1431 community-dwelling older women (mean age ± SD; 75.2 ± 2.7 years) were included in over 14.5 years of a prospective study, the Perth Longitudinal Study of Ageing in Women. CVD (up to 18-years prior to the baseline visit) and injurious fall hospitalizations over 14.5 years were obtained from linked health records. Self-reported falls for five …
A Case Of Galeazzi Fracture Subluxation Of Left Forearm In Paediatric Age Group, Sauparna Dey
A Case Of Galeazzi Fracture Subluxation Of Left Forearm In Paediatric Age Group, Sauparna Dey
Digital Journal of Clinical Medicine
A case report of a rare form of fracture- Galeazzi fracture subluxation in paediatric age group. Showing post operative progress of the patient, with a discussion on possible methodology of approaching such fractures. Correct management of the fracture is essential for proper healing and avoiding complications.
Autonomic Function Recovery And Physical Activity Levels In Post-Covid-19 Young Adults After Immunization: An Observational Follow-Up Case-Control Study, Ana Paula Coelho Figueira Freire, Shaan Amin, Fabio Santos Lira, Ana Elisa Von Ah Morano, Telmo Pereira, Manuel-João Coelho-E-Silva, Armando Caseiro, Diego Giulliano Destro Christofaro, Vanessa Ribeiro Dos Santos, Osmar Marchioto Júnior, Ricardo Aurino Pinho, Bruna Spolador De Alencar Silva
Autonomic Function Recovery And Physical Activity Levels In Post-Covid-19 Young Adults After Immunization: An Observational Follow-Up Case-Control Study, Ana Paula Coelho Figueira Freire, Shaan Amin, Fabio Santos Lira, Ana Elisa Von Ah Morano, Telmo Pereira, Manuel-João Coelho-E-Silva, Armando Caseiro, Diego Giulliano Destro Christofaro, Vanessa Ribeiro Dos Santos, Osmar Marchioto Júnior, Ricardo Aurino Pinho, Bruna Spolador De Alencar Silva
All Faculty Scholarship for the College of Education and Professional Studies
Coronavirus disease 2019 (COVID-19) has detrimental multi-system consequences. Symptoms may appear during the acute phase of infection, but the literature on long-term recovery of young adults after mild to moderate infection is lacking. Heart rate variability (HRV) allows for the observation of autonomic nervous system (ANS) modulation post-SARS-CoV-2 infection. Since physical activity (PA) can help improve ANS modulation, investigating factors that can influence HRV outcomes after COVID-19 is essential to advancements in care and intervention strategies. Clinicians may use this research to aid in the development of non-medication interventions. At baseline, 18 control (CT) and 20 post-COVID-19 (PCOV) participants were …
Reliability Of Hand-Held Dynamometry For Measuring Force Production In People With Parkinson’S Disease, Matthew Boom, Elisabeth Preston, Renee Salmon, Louise Ada, Allyson Flynn
Reliability Of Hand-Held Dynamometry For Measuring Force Production In People With Parkinson’S Disease, Matthew Boom, Elisabeth Preston, Renee Salmon, Louise Ada, Allyson Flynn
Internet Journal of Allied Health Sciences and Practice
Purpose: People with Parkinson’s disease (PD) have impaired force production, which is associated with decreased mobility and falls risk. Reliable measurement of force production is important. Design: A repeated-measures, intra- and inter-rater reliability study was undertaken. Participants: 24 people with mild PD were measured by one or two raters. Outcome measures: Isometric force of the major upper and lower limb muscle groups was measured using hand-held dynamometry. Results: Fourteen participants were measured by the same rater on two occasions to determine intra-rater reliability. Ten participants were measured on two occasions by two different raters to determine …
The Impact Of Physical Activity Education During Pregnancy, Lizeth Banuchi
The Impact Of Physical Activity Education During Pregnancy, Lizeth Banuchi
DNP Research Projects
Abstract
Background: Physical Activity (PA) during pregnancy is important to maintain optimal maternal and neonatal health. Gestational Diabetes Mellitus (GDM) requires close monitoring during pregnancy due to the health risk it can cause to mother and fetus. It is evident that PA can help improve maternal health outcomes to positively offer overall wellness throughout the pregnancy.
Objective: The purpose of this Quality Improvement Project (QIP) is to evaluate the impact of PA education on PA implementation during pregnancy and improve clinical practice for healthcare providers to introduce PA education during prenatal care per ACOG and CESP guidelines.
Method: This quality …
Meningitis In Hiv Positive And Negative Patients: A Comparative Demographic Profile., Sridhar Amalakanti, Jyothi Priya Jillella, Krishna Sagar Gajula
Meningitis In Hiv Positive And Negative Patients: A Comparative Demographic Profile., Sridhar Amalakanti, Jyothi Priya Jillella, Krishna Sagar Gajula
Digital Journal of Clinical Medicine
Background: Meningitis is a serious infection in HIV patients claiming millions of lives across the world. Comparative studies of meningitis in HIV positive and negative patients are scarce. Methods: We performed a comparative study of the demographic features of meningitis in HIV positive [116] and HIV negative [218] patients at a tertiary hospital over a period of four years. Results: In HIV seropositive patients the percentage of women was lesser [29.6% vs. 42.5%], the proportion of students was lesser [4.8% vs.14%], but the proportion of professionals was higher [17.5% vs. 10.8%] when compared to HIV seronegative group. Even though Tuberculosis …
Does Lower-Limb Osteoarthritis Alter Motor Cortex Descending Drive And Voluntary Activation? A Systematic Review And Meta-Analysis, Myles C. Murphy, Christopher Latella, Ebonie K. Rio, Janet L. Taylor, Stephanie Martino, Colin Sylvester, William Hale, Andrea B. Mosler
Does Lower-Limb Osteoarthritis Alter Motor Cortex Descending Drive And Voluntary Activation? A Systematic Review And Meta-Analysis, Myles C. Murphy, Christopher Latella, Ebonie K. Rio, Janet L. Taylor, Stephanie Martino, Colin Sylvester, William Hale, Andrea B. Mosler
Research outputs 2022 to 2026
Purpose: The aim of the study was to quantify motor cortex descending drive and voluntary activation (VA) in people with lower-limb OA compared to controls. Methods: A systematic review and meta-analysis according to the PRISMA guidelines was carried out. Seven databases were searched until 30 December 2022. Studies assessing VA or responses to transcranial magnetic stimulation (TMS; i.e. motor evoked potential, intracortical facilitation, motor threshold, short-interval intracortical inhibition, and silent period) were included. Study quality was assessed using Joanna Briggs Institute criteria and evidence certainty using GRADE. The meta-analysis was performed using RevMan inverse variance, mixed-effect models. Results: Eighteen studies …
Fight-Pd: A Feasibility Study Of Periodized Boxing Training For Parkinson Disease, David J. Blacker, Raimondo Fazio, Claire Tucak, Phillip Beranek, Connor Pollard, Tegan Shelley, Sanathraj Rajandran, Georgina Holbeche, Mitchell Turner, Travis Cruickshank
Fight-Pd: A Feasibility Study Of Periodized Boxing Training For Parkinson Disease, David J. Blacker, Raimondo Fazio, Claire Tucak, Phillip Beranek, Connor Pollard, Tegan Shelley, Sanathraj Rajandran, Georgina Holbeche, Mitchell Turner, Travis Cruickshank
Research outputs 2022 to 2026
Background: Boxing training has become a popular form of exercise for people with Parkinson disease (PD). There is a dearth of high-quality feasibility, safety, and efficacy data on boxing training for PD. Feasibility of Instituting Graduated High-intensity Training (FIGHT-PD) aimed to examine these features in a periodized boxing training program featuring high-intensity physical and cognitive demands. Objective: To conduct a feasibility study, aiming to address deficiencies in the current knowledge base and to provide data for future studies. Design: Single-arm, open-label feasibility. Setting: University department and medical research institute. Participants: Ten people with early stage PD without contraindications to intense …
Multimodal Exercise In Older Patients With Advanced Pancreatic Cancer Undergoing First-Line Chemotherapy: A Case Series Examining Feasibility And Preliminary Efficacy, Hao Luo, Daniel A. Galvão, Robert U. Newton, Colin I. Tang, Nigel Spry, Dennis R. Taaffe
Multimodal Exercise In Older Patients With Advanced Pancreatic Cancer Undergoing First-Line Chemotherapy: A Case Series Examining Feasibility And Preliminary Efficacy, Hao Luo, Daniel A. Galvão, Robert U. Newton, Colin I. Tang, Nigel Spry, Dennis R. Taaffe
Research outputs 2022 to 2026
Purpose. Exercise is emerging as an adjunct therapy to cancer treatment; however, its role in older patients with advanced pancreatic cancer undergoing first-line chemotherapy is unclear. The aim of this study was to primarily provide evidence on feasibility with an exploratory examination of the initial efficacy of exercise in this clinical setting.
Materials and Methods. Six patients aged 60–75 years with de novo or recurrent advanced pancreatic cancer undergoing first-line chemotherapy consented to participate in twice-weekly exercise that included resistance and aerobic training and boxing-related activities for up to 12 weeks. Patients were monitored for attendance, adherence, and …