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Articles 1 - 11 of 11
Full-Text Articles in Medicine and Health Sciences
Use Of Mechanical Pronation Beds In Acute Respiratory Distress Syndrome In The Intensive Care Unit: An Integrative Review Of The Literature, Amanda St. John
Use Of Mechanical Pronation Beds In Acute Respiratory Distress Syndrome In The Intensive Care Unit: An Integrative Review Of The Literature, Amanda St. John
Honors Undergraduate Theses
The increasing rate of Acute Respiratory Distress Syndrome (ARDS) reinforces the need for additional resources to assist clinical staff with an individual's care and recovery. Pronation therapy involves physically rotating an individual from the posterior position to the prone position. Pronation therapy has successfully been used for individuals diagnosed with ARDS in Intensive Care Units for decades. However, manual pronation maneuvers by staff members poses risks for those who are critically ill and risk of physical injury to caregivers. Mechanical pronation beds have revolutionized the art of pronation therapy, minimizing risks, and decreasing possibility of kinking or pulling out life …
Role Of Rela In Dormancy And Toxr Proteolysis In Vibrio Cholerae, Zachary J. Malaussena
Role Of Rela In Dormancy And Toxr Proteolysis In Vibrio Cholerae, Zachary J. Malaussena
Honors Undergraduate Theses
Vibrio cholerae, the etiological agent of the severe diarrheal disease cholera, is an enteric pathogen that can be found in aquatic ecosystems when not colonizing the human gastrointestinal tract. Under adverse environmental conditions, V. cholerae is capable of entering dormant states that increase its survival during these ecological fluctuations. In these states, V. cholerae slows its metabolic activity and exhibits drastically altered gene expression and morphology. Stressors that lead to entry into these states vary from nutrient limitation, suboptimal pH, or antimicrobials. Cells in these dormant states are highly resistant to antimicrobials and cannot be detected using standard microbiological techniques …
Developing A Targeted Ultrasound-Responsive Nanobubble-Based Gene Delivery System For Osteoporosis Treatment, Angela Shar
Developing A Targeted Ultrasound-Responsive Nanobubble-Based Gene Delivery System For Osteoporosis Treatment, Angela Shar
Honors Undergraduate Theses
The overall goal of this project was to develop, optimize, and test an ultrasound-responsive targeted nanobubble for delivering osteoporosis-related silencing genes such as Cathepsin K small interfering RNA (CTSK siRNA) for osteoporosis treatment. The nanobubbles were synthesized using an in situ sonochemical method. The nanobubble (NB) is composed of a gas core made from perfluorocarbon, stabilized with albumin, encapsulated with CTSK siRNA, and embedded with alendronate (AL) for bone targeting (CTSK siRNA-NB-AL). Following its development, the responsiveness of CTSK siRNA-NB-AL to a therapeutic ultrasound probe was examined. The results of biocompatibility tests with human bone marrow-derived mesenchymal stem cells proved …
Modeling And Analysis Of Covid-19 And Dynamical Systems In Biology And Physics, Vladimir Grbic
Modeling And Analysis Of Covid-19 And Dynamical Systems In Biology And Physics, Vladimir Grbic
Honors Undergraduate Theses
In this paper, we study various examples of dynamical systems found in nature and extract the necessary concepts to build upon. Then, we develop and propose a new deterministic model for COVID-19 propagation. Our model should serve two purposes. First, we will approximate the infected and deceased individuals after a given time during the pandemic. Then, using a linearized subsystem describing infectious compartments about the disease- free equilibrium (DFE), we will determine the basic reproductive number (R0) by the next-generation matrix method.
The Fighting Journey Of A Premature Baby: A Systemic Review Of Developmental And Neurological Complications Of The Premature Baby, Dana Patel
Honors Undergraduate Theses
Prematurity is a worldwide problem. Every year, 15 million babies are born prematurely, and 1 million of those babies die because of related complications. The surviving premature babies are struggling to hold on to their lives, and even when they do live, most of them end up having various complications to survive and get stronger. There are physical complications faced on their journey such as having underdeveloped lungs, pneumonia, obesity, sepsis, retinopathy of prematurity, respiratory distress syndrome, bronchopulmonary dysplasia, asthma, wheezing, bronchiolitis, cerebral palsy, and motor impairment. They can also develop mental and behavioral health complications such as depression, seizures …
Sequence-Independent Assay For Hiv Viral Load Quantitation, Omar El Merhebi
Sequence-Independent Assay For Hiv Viral Load Quantitation, Omar El Merhebi
Honors Undergraduate Theses
Although nucleic acid tests (NATs) for human immunodeficiency virus (HIV) exhibit many advantages, such as early detection and viral load quantification, over immunological assays, their widespread use is limited by their demand for high-level infrastructure, sophisticated equipment, and advanced staff competence. Furthermore, when quantifying viral loads of patients, it has been reported that these assays can underestimate viral quantities by 22- to 100-fold due to primer-template mismatches in more divergent HIV subtypes. Therefore, we have developed a cost-effective and sequence-independent assay for the detection and quantification of HIV utilizing a modified nucleic acid sequence-based amplification (NASBA) protocol coupled to an …
Using A Lubricin Reporter Cell To Test Current Vs. Optimized Media Compositions, Sean M. Kennedy
Using A Lubricin Reporter Cell To Test Current Vs. Optimized Media Compositions, Sean M. Kennedy
Honors Undergraduate Theses
Osteoarthritis is a joint disease characterized by the breakdown of articular cartilage. The field of tissue engineering is interested in developing methods to produce biological alternatives to current orthopedic procedures. Lubricin is a molecule which is important in the proper lubrication of articular cartilage. It is a challenge in the field of tissue engineering to produce cartilage with sufficient lubricin expression. Developing a reporter cell for lubricin allowed for a more efficient investigation of the conditions which may influence its expression. By comparing "optimized" and traditional media solutions, it was determined that the use of a previously reported type II …
Acoustic Detection Of Developmental Dysplasia Of The Hip In Models Representing Neonates, Pinak Raodeo
Acoustic Detection Of Developmental Dysplasia Of The Hip In Models Representing Neonates, Pinak Raodeo
Honors Undergraduate Theses
Developmental dysplasia of the hip (DDH) is a condition that involves the dislocation of the head of the femur in the acetabulum of the pelvic bone. Although it may not interfere with a child's range of motion during infancy, DDH can cause various effects over time such as joint pain, abnormal gait, and even paralysis. It is crucial to catch this phenomenon early on so that permanent disability is not introduced to the patient. In this study, an excitation device was used to send a broadband frequency signal through a hip joint simulated by a 3D printed bone apparatus consisting …
High Rates Of Misdiagnosis Of Pediatric Acute-Onset Neuropsychiatric Syndrome And How To Reduce Them, Aliya Centner
High Rates Of Misdiagnosis Of Pediatric Acute-Onset Neuropsychiatric Syndrome And How To Reduce Them, Aliya Centner
Honors Undergraduate Theses
Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) is a clinical diagnosis characterized by sudden onset of obsessive compulsive disorder and is considered a type of Autoimmune Encephalitis. Pediatric Autoimmune Neuropsychiatric Disorder associated with Streptococcal Infection (PANDAS) is a subset of PANS characterized by a similar presentation but specifically results from infection by Group A β-hemolytic streptococcus. Early and accurate diagnosis is essential, as PANS can become a chronic condition. PANS and PANDAS are frequently misdiagnosed. There are a variety of differential diagnoses. The intent of this thesis is to evaluate differences in symptoms between PANDAS patients and those with a differential diagnosis …
Disparities In The 2009 Swine Flu Pandemic And Covid-19: A Literature Review, Yusuf Amawi
Disparities In The 2009 Swine Flu Pandemic And Covid-19: A Literature Review, Yusuf Amawi
Honors Undergraduate Theses
The purpose of this thesis was to identify causes of disparities in affliction (infection) and mortality for minority populations (Blacks, Hispanics, Asians, and American Indian/Alaskan Natives) during the Swine Flu (H1N1) and COVID-19 (Sars-Cov-2) Pandemics. A literature review was conducted gathering peer-reviewed journal articles related to racial and socioeconomic disparities in affliction and mortality during both pandemics. The model of Blumenshine et al. (2008) was used as a guide for the analysis of this thesis, and measures of exposure, susceptibility, and treatment were hypothesized as causes for the disparities experienced by the minority populations during the two pandemics. Ultimately, it …
Covid-19 Infection In Hypertensive Patients In Correlation With Race, Elizabeth Durkin
Covid-19 Infection In Hypertensive Patients In Correlation With Race, Elizabeth Durkin
Honors Undergraduate Theses
Disparities in healthcare exist in the U.S., particularly between different racial categories. This study investigated the frequency of COVID-19 cases and hypertension cases among five different racial groups (White, Black, Asian, Native American, and Native Hawaiian). The study also examined the correlation between COVID-19 and hypertension. It was hypothesized that, because of genetic predisposition to certain diseases and existing socioeconomic barriers, Black populations would have the highest rates of both COVID-19 and hypertension. It was also proposed that a positive correlation exists between COVID-19 and hypertension frequency. To test this, the Kaiser Family Foundation's data for COVID-19 cases and race …