Medicine and Health Sciences Commons^™

Primary Aortic Valve Replacement In Adults From Age 45 To 65 And How Their Survivability, Post Replacement, May Be Affected By Opting For A Bioprosthetic Or Mechanical Valve., Chandler Hutchinson

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Abstract:

Introduction: Aortic valve replacement in middle-aged adults is a procedure done when the aortic valve becomes so incompetent, that replacement is the only viable option for the patient. A bioprosthetic or a mechanical valve is then chosen and replaces the patients’ native aortic valve. For these adults, this procedure is life-extending and the only option for prolonged survival. This paper will address whether a bioprosthetic or mechanical valve would be the better option for prolonging a middle-aged patients’ life.

Methods: A literature search was completed in November of 2019 using PubMed and Google Scholar. Seven articles were chosen based …

Management Of Refractory Ventricular Fibrillation With Double Sequential Defibrillation, Kaitlyn A. Brown

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Patients experiencing cardiac arrest are treated according to ACLS protocols, however current protocols lack recommendations for the treatment of refractory Ventricular Fibrillation which persists after more than 3 cycles of CPR and defibrillation. One potential intervention for these cases that is being researched is the use of simultaneous or sequential activation of two defibrillators. This literature review analyzed the results of several studies to determine if double sequential defibrillation (DSD) is a viable treatment to achieve return of spontaneous circulation (ROSC) and improved patient survival. The results of the studies were mixed with some showing positive outcomes, and others showing …

Therapeutical Studies Of The Disrupted Cftr Gene In Affected Sheep And Rabbit Models Produced By Genome Editor Crispr/Cas9, Nicole Teberio

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Cystic Fibrosis (CF) is a life-threatening, autosomal recessive disorder caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Patients with CF have a decreased lifespan due to complications with lung infections/disease, decreased airway function, and persistent cough with phlegm. Over the past few decades, scientists have contributed to CF research by using animal models to understand the pathology of the disease. The models selected have similar pathogenesis to humans, so they are key insights for understanding the effects of CFTR gene malfunctions. More recently, animal models, such as CRISPR generated sheep and rabbits used in the two current …

Efficacy Of Sublingual Immunotherapy In The Treatment Of House-Dust Mite Induced Allergic Rhinitis, Sirena Saleet

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Introduction: House-dust mite (HDM) induced allergic rhinitis (AR) is a chronic condition associated with rhinorrhea, nasal obstruction, nasal pruritus and sneezing. The current mainstay of treatment is intranasal corticosteroids, which have shown variable degrees of symptom control among patients. Chronic use is typically required to achieve continued relief. Immunotherapy works to increase peripheral immune tolerance by administration of the allergen itself. Not only does it have the potential to decrease acute symptoms of allergic rhinitis, but it is also the sole treatment offering disease-modifying potential with long-term use. Immunotherapy is an option which can eliminate both the chronic administration …

Comparing Melatonin Use To Bright Light Therapy In Mitigating Cardiovascular Effects Due To Shift Work Disorder In Shift Working Adults, Alexandra Hirt

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Introduction: Circadian Misalignment is a term used to describe a mismatch in one’s physiologically determined sleep patters and their actual sleep wake behaviors. Shift workers often end up in a vicious cycle of being in a state of chronic circadian misalignment, which then can lead to health problems, extreme fatigue, and insomnia, known as Shift Work Disorder (SWD).This has been studied in night shift workers who, when compared to daytime workers, have an increased risk of developing metabolic syndrome, type 2 diabetes, and coronary heart disease.These results are not dependent on any behavioral risk factors, such as smoking and poor …

Land-Based Exercise Versus Hydrotherapy In Osteoarthritis, Alyson Rivers

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Introduction: Osteoarthritis is the most common form of arthritis. It results in joint pain, stiffness, reduced mobility, and decreased quality of life. While NSAIDs are the cornerstone of treatment, exercise is one of the safest and least expensive treatments. Exercise can be completed on land or in water. Hydrotherapy is hypothesized to produce more beneficial outcomes compared to land-based exercise.

Methods: The database, PubMed, was used to acquire articles that compare hydrotherapy to land-based therapy in individuals with large-joint OA. Outcomes of interest included pain relief, joint mobility, and quality of life.

Results: Based collectively on four articles, there was …

The Efficacy Of Mirnas As A Diagnostic Tool For Endometriosis, Maura Franey

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Abstract

Introduction: Endometriosis is a chronic inflammatory gynecological condition. Laparoscopic abdominopelvic exploration is the gold standard of diagnosis, but is not performed until patients experience severe symptoms. This review analyzes the levels of circulating micro-RNAs (miRNAs) (I) for diagnosis of endometriosis (O) in women diagnosed with endometriosis (P) compared to laparoscopic exploration (C).

Methods: A literature search was conducted through PubMed and Cochrane Library in November 2019. A total of nine articles consisting of case-control or systematic reviews were selected based on publication date, main outcome, and the use of miRNAs or laparoscopy for diagnosis of endometriosis.

Results: The eight …

Efficacy Of Anti-Mullerian Hormone In The Diagnosis Of Polycystic Ovarian Syndrome, Cassidy Prewitt

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Introduction: Polycystic ovarian syndrome (PCOS) is a complex condition that presents with a wide variety of symptoms. The PCOS diagnosis standard is the Rotterdam criteria, which includes hyperandrogenism, oligo-anovulation, and polycystic ovarian morphology (PCOM). Transvaginal ultrasounds have traditionally been used to evaluate PCOM, however, they are highly dependent on technician skill. This paper will evaluate research regarding the use of anti-Mullerian (AMH) in PCOS diagnosis as an alternative to transvaginal ultrasound.

Methods: A literature search was conducted using PubMed and Academic Search Ultimate in January 2020. A total of eight articles were selected based on relevance to the research topic …

The Role Of Cannabidiol In The Treatment Of Pediatric Patients With Refractory Epilepsy, Evan Chidley

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THE ROLE OF CANNABIDIOL IN THE TREATMENT OF PEDIATRIC PATIENTS WITH REFRACTORY EPILEPSY

Author(s) and affiliations: Evan Chidley¹, MMS (c), MPH (c)

¹Arcadia University; echidley@arcadia.edu; (515) 201-6901

Introduction: Intractable epilepsy in children can significantly impair quality of life and anti-epileptic drugs (AEDs) do not adequately reduce seizures for all pediatric patients. Recently, cannabidiol (CBD), one of the main compounds of marijuana, has shown promise as a potential treatment for uncontrolled seizure activity. This paper poses the following question: In pediatric patients with drug-resistant epilepsy, is cannabidiol (CBD) more effective in reducing seizure activity than traditional anti-epileptic drugs …

Biometric Prognosticators Of Future Myocardial Infarction: Bmi Vs. Waist To Hip Ratio, Christopher Hover

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Introduction: Myocardial Infarction (MI), better known as a heart attack, occurs when one or more of the coronary arteries becomes blocked or clogged to the point of being unable to perfuse myocardial tissue. Standard biometric measurements when visiting an outpatient care provider include height and weight which are converted into body mass index (BMI). BMI can sometimes be misleading in judging future health outcomes such as heart attacks. Therefore, this review analyzes the use of waist to hip ratio (I) to predict future myocardial infarctions (P) subsequently to prevent such events (O) compared to the traditionally used metric of BMI …