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Full-Text Articles in Medicine and Health Sciences
Host Species Restriction Of Middle East Respiratory Syndrome Coronavirus Through Its Receptor, Dipeptidyl Peptidase 4, Neeltje Van Doremalen, Kerri L. Miazgowicz, Shauna Milne-Price, Trenton Bushmaker, Shelly Robertson, Dana Scott, Joerg Kinne, Jason S. Mclellan
Host Species Restriction Of Middle East Respiratory Syndrome Coronavirus Through Its Receptor, Dipeptidyl Peptidase 4, Neeltje Van Doremalen, Kerri L. Miazgowicz, Shauna Milne-Price, Trenton Bushmaker, Shelly Robertson, Dana Scott, Joerg Kinne, Jason S. Mclellan
Dartmouth Scholarship
Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012. Recently, the MERS-CoV receptor dipeptidyl peptidase 4 (DPP4) was identified and the specific interaction of the receptor-binding domain (RBD) of MERS-CoV spike protein and DPP4 was determined by crystallography. Animal studies identified rhesus macaques but not hamsters, ferrets, or mice to be susceptible for MERS-CoV. Here, we investigated the role of DPP4 in this observed species tropism. Cell lines of human and nonhuman primate origin were permissive of MERS-CoV, whereas hamster, ferret, or mouse cell lines were not, despite the presence of DPP4. Expression of human DPP4 in nonsusceptible BHK and …
The Spread And Potential Control Of Disease Across The Domestic Cattle-Wildlife Interface, Rachel Jackson
The Spread And Potential Control Of Disease Across The Domestic Cattle-Wildlife Interface, Rachel Jackson
Chancellor’s Honors Program Projects
No abstract provided.
Steer Stress Response As Affected By Genotype And Transportation, Megan Wary, Marites Sales, Ben Williamson, Ken Coffey, Michael Looper, Charles Rosenkrans Jr.
Steer Stress Response As Affected By Genotype And Transportation, Megan Wary, Marites Sales, Ben Williamson, Ken Coffey, Michael Looper, Charles Rosenkrans Jr.
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
Bovine cytochrome P450 3A28 is responsible for metabolizing ergot alkaloids that cattle ingest when feeding on endophyte-infested tall fescue grass. The objective of this research was to determine associations among genotype, transportation, and stress responses. Angus crossbred steers (n = 47) were genotyped (CC, CG, or GG) for a single-nucleotide polymorphism (C994G) in cytochrome P450 3A28. Genotypes were determined by polymerase chain reaction (PCR) amplification followed by restriction enzyme (Alu1) digestion. Steers were backgrounded on a mixedcultivar tall fescue pasture. Following the stocker phase, steers were transported to the feedlot for finishing. Stress responses were determined 27 h prior to, …