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Full-Text Articles in Medicine and Health Sciences
Effects Of A Multicomponent Wellness Intervention On Dyslipidemia In An Overweight Adolescent Population, Olga T. Hardy, Jean Wiecha, Albert Kim, Carlos Salas, Rayna Bricenoc, Kwesi Moody, Joan Becker, Greer Glazer, Carol A. Ciccarelli, Ling Shi, Laura L. Hayman
Effects Of A Multicomponent Wellness Intervention On Dyslipidemia In An Overweight Adolescent Population, Olga T. Hardy, Jean Wiecha, Albert Kim, Carlos Salas, Rayna Bricenoc, Kwesi Moody, Joan Becker, Greer Glazer, Carol A. Ciccarelli, Ling Shi, Laura L. Hayman
Laura L. Hayman
Epidemiologic studies suggest that atherosclerotic processes begin in childhood and are associated with abnormal lipid levels. Behavioral changes are the first line of treatment for dyslipidemia in adolescents but outcome data on the effectiveness of this approach are inconsistent. This study aimed to assess the effect of a 13-week multicomponent wellness intervention program on dyslipidemia in lean and overweight/obese adolescents enrolled at a public high school in Boston, Massachusetts. The intervention was conducted at a university-based youth fitness center where 9 overweight/obese adolescents (body mass index [BMI]≥85th percentile for age and sex) and 9 lean adolescents (BMIsex) participated in weekly …
Interventions To Promote Physical Activity And Dietary Lifestyle Changes For Cardiovascular Risk Factor Reduction In Adults: A Scientific Statement From The American Heart Association, Nancy Trygar Artinian, Gerald F. Fletcher, Dariush Mozaffarian, Penny Kris-Etherton, Linda Van Horn, Alice H. Lichtenstiein, Shiriki Kumanyika, William E. Kraus, Jerome J. Fleg, Nancy S. Redeker, Janet C. Meininger, Joanne Banks, Eileen M. Stuart-Shor, Barbara J. Fletcher, Todd D. Miller, Suzanne Hughes, Lynn T. Braun, Laurie A. Kopin, Kathy Berra, Laura L. Hayman, Linda J. Ewing, Philip A. Ades, J. Larry Durstine, Nancy Houston-Miller, Lora E. Burke
Interventions To Promote Physical Activity And Dietary Lifestyle Changes For Cardiovascular Risk Factor Reduction In Adults: A Scientific Statement From The American Heart Association, Nancy Trygar Artinian, Gerald F. Fletcher, Dariush Mozaffarian, Penny Kris-Etherton, Linda Van Horn, Alice H. Lichtenstiein, Shiriki Kumanyika, William E. Kraus, Jerome J. Fleg, Nancy S. Redeker, Janet C. Meininger, Joanne Banks, Eileen M. Stuart-Shor, Barbara J. Fletcher, Todd D. Miller, Suzanne Hughes, Lynn T. Braun, Laurie A. Kopin, Kathy Berra, Laura L. Hayman, Linda J. Ewing, Philip A. Ades, J. Larry Durstine, Nancy Houston-Miller, Lora E. Burke
Laura L. Hayman
Even modest sustained lifestyle changes can substantially reduce cardiovascular disease (CVD) morbidity and mortality. Because many of the beneficial effects of lifestyle changes accrue over time, long-term adherence maximizes individual and population benefits. Interventions targeting dietary patterns, weight reduction, and new PA habits often result in impressive rates of initial behavior changes, but frequently are not translated into long-term behavioral maintenance. Both adoption and maintenance of new cardiovascular risk-reducing behaviors pose challenges for many individuals. According to the National Center for Health Statistics, life expectancy could increase by almost 7 years if all forms of major CVD were eliminated.5 Improvements …
Task Force #4--Adherence Issues And Behavior Changes: Achieving A Long-Term Solution. 33rd Bethesda Conference, Ira Ockene, Laura Hayman, Richard Pasternak, Eleanor Schron, Jacqueline Dunbar-Jacob
Task Force #4--Adherence Issues And Behavior Changes: Achieving A Long-Term Solution. 33rd Bethesda Conference, Ira Ockene, Laura Hayman, Richard Pasternak, Eleanor Schron, Jacqueline Dunbar-Jacob
Laura L. Hayman
Adherence (equivalent to compliance) to lifestyle and medication recommendations for the prevention of cardiovascular disease (CVD) is a crucial element in the path from the science of risk-factor modification to the actual reduction of risk factors and consequent prevention of disease-related events. This Task Force Report presents an overview of the evidence supporting multilevel strategies for improving the adherence to lifestyle and pharmacologic interventions. Building on available adherence data and consistent with the theme of this Bethesda Conference, suggestions for advancing CVD prevention on both an individual and population level are also offered.
Increased Toll-Like Receptor (Tlr) Mrna Expression In Monocytes Is A Feature Of Metabolic Syndrome In Adolescents, Olga Hardy, Albert Kim, Carol Ciccarelli, Laura Hayman, Jean Wiecha
Increased Toll-Like Receptor (Tlr) Mrna Expression In Monocytes Is A Feature Of Metabolic Syndrome In Adolescents, Olga Hardy, Albert Kim, Carol Ciccarelli, Laura Hayman, Jean Wiecha
Laura L. Hayman
BACKGROUND: Metabolic syndrome (MetSyn) is diagnosed frequently in some but not all overweight adolescents. Chronic inflammation, as seen in obesity, is strongly associated with MetSyn. OBJECTIVES: The aim of this pilot study was to assess the correlation between activation of the innate immune system and MetSyn, independent of body mass index (BMI), in a young population. METHODS: We quantitatively measured both systemic pro-inflammatory cytokines and gene expression of Toll-like receptors (TLRs) and downstream cytokines in circulating monocytes obtained from nine adolescents with metabolic syndrome (Overwt-MetSyn) and eight BMI-matched controls (Overwt-Healthy). RESULTS: The Overwt-MetSyn group demonstrated a significant elevation in expression …
Role Of Inflammatory Monocytes In Adolescent Metabolic Syndrome, Olga T. Hardy, Albert Kim, Carol Ciccarelli, Laura L. Hayman, Jean Wiecha
Role Of Inflammatory Monocytes In Adolescent Metabolic Syndrome, Olga T. Hardy, Albert Kim, Carol Ciccarelli, Laura L. Hayman, Jean Wiecha
Laura L. Hayman
Metabolic syndrome (MetSyn) is a cluster of risk factors for cardiovascular disease and diabetes that affects 1 in 3 obese children. Inflammatory cytokines secreted from macrophages are thought to be partly responsible for the metabolic abnormalities associated with MetSyn. This study aimed to determine whether peripheral blood monocytes (macrophage precursors) from overweight individuals with MetSyn (Overwt-MetSyn) demonstrate enhanced activation of inflammatory signaling pathways when compared to metabolically normal overweight (Overwt-Healthy) or lean individuals. We conducted a cross sectional pilot study involving 24 adolescents (six boys and eighteen girls) recruited from the University of Massachusetts Boston and Worcester campuses. Six subjects …