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Full-Text Articles in Medicine and Health Sciences
The Impact Of Being Born With Cleft And Cleft Reparative Surgery On Overall Health And Speech Outcomes, Khatansuudal Evsanaa
The Impact Of Being Born With Cleft And Cleft Reparative Surgery On Overall Health And Speech Outcomes, Khatansuudal Evsanaa
Master's Theses
Orofacial cleft is one of the most common and treatable birth defects in the world. If left untreated, orofacial cleft can impair normal speech development, growth, and could lead to a number of health consequences later in life. The main motivation of the study is to measure the impact of being born with cleft and the cleft reparative surgery on overall speech and health cleft for teenagers in India using difference-in-differences approach along with household fixed effects method. An overall health outcome was measured using height, weight, grip strength and BMI, and the speech acceptability was measured using a “Universal …
Methods For Detection Of Matrix Metalloproteinases As Biomarkers In Cardiovascular Disease, Viorica Lopez-Avila, Juliet Spencer
Methods For Detection Of Matrix Metalloproteinases As Biomarkers In Cardiovascular Disease, Viorica Lopez-Avila, Juliet Spencer
Biology Faculty Publications
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes that degrade extracellular matrix (ECM) components like collagen, fibronectin, and laminin. While this activity is important for normal development, morphogenesis, and wound healing, deregulation of MMP activity has been implicated in a number of cardiovascular diseases, including congenital heart defects, atherosclerosis, myocardial infarction, and congestive heart failure. MMPs are good potential diagnostic indicators of cardiovascular disease, but current detection methods are time consuming and quite laborious. This review will discuss MMP biology, current methods for detection of MMPs from patient samples, and potential new developments in multiplexed analysis of MMPs.