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The Effects Of Classic And Variant Infectious Bursal Disease Viruses On Lymphocyte Populations In Specific-Pathogen-Free White Leghorn Chickens, Christina L. Johnson, Ashley K. Cox, April D. Keeter, Will J. Quinn, Gisela F. Erf, Lisa A. Newberry
The Effects Of Classic And Variant Infectious Bursal Disease Viruses On Lymphocyte Populations In Specific-Pathogen-Free White Leghorn Chickens, Christina L. Johnson, Ashley K. Cox, April D. Keeter, Will J. Quinn, Gisela F. Erf, Lisa A. Newberry
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
Infectious bursal disease virus (IBDV) is a pathogen that primarily infects B lymphocytes in domestic avian species. This viral infection has been associated with immunosuppression, clinical disease/mortality, and enteric malabsorption effects. The purpose of this experiment was to compare the effects of a classic (USDA-STC) and a new variant IBDV (RB-4, known to induce primarily the enteric disease) on immune cell populations in lymphoid organs. Seventeen-dayold specific-pathogen-free (SPF) White Leghorn chickens were either not infected (control) or inoculated with either USDA-STC or RB-4 IBD viral isolate. On days 3 and 5 post-inoculation (PI), lymphoid tissues were collected to prepare cell …