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Full-Text Articles in Medicine and Health Sciences
Effect Of N-Acetyl-L-Cysteine Prevention Or Intervention On Diet Induced Beta Cell Compensation And Dysfunction, Madison Wallace
Effect Of N-Acetyl-L-Cysteine Prevention Or Intervention On Diet Induced Beta Cell Compensation And Dysfunction, Madison Wallace
Electronic Thesis and Dissertation Repository
Type 2 diabetes mellitus (T2DM) progression increases oxidative stress which contributes to beta cell compensation and eventual dysfunction. To investigate the role of antioxidant N-acetyl-L-cysteine (NAC) on beta cell function and pancreatic stellate cell activation (aSMA+) during early and late stages of compensation, NAC was used for preventative (p) and intervention (i) treatments in C57BL/6N mice fed a 60% kcal high-fat diet (HFD) for 8 or 22 weeks. Significantly improved glucose tolerance was observed at 22 weeks following pNAC treatment in HFD mice. Although 22-week HFD mice displayed hyperinsulinemia, beta cell hypertrophy, decreased beta cell PDX-1 nuclear localization, …
Novel Mechanisms And Biomarkers In Alcohol-Induced Organ Injury., Christine E. Dolin
Novel Mechanisms And Biomarkers In Alcohol-Induced Organ Injury., Christine E. Dolin
Electronic Theses and Dissertations
Background. Ethanol (EtOH) consumption is known to affect multiple organs; this is unsurprising, as the concentration of EtOH in the blood at relevant doses reaches the millimolar range. The overarching goal of this dissertation was to elucidate mechanisms of alcohol-induced organ injury, specifically the effects of alcohol on the hepatic extracellular matrix (ECM) proteome, the alcoholic hepatitis (AH) plasma peptidome, and the effects of alcohol on the renal cortex proteome and transcriptome. Methods. Mice were pair-fed ethanol-containing liquid diet chronically, and then some mice were administered lipopolysaccharide (LPS). Liver sections from these mice were processed in a series of increasingly …
The Effects Of Intermittent Fasting On Chronic Disease In Adults: A Systematic Review, Brendan Teeters
The Effects Of Intermittent Fasting On Chronic Disease In Adults: A Systematic Review, Brendan Teeters
Undergraduate Honors Theses
This systematic review investigated thirteen primary and secondary research studies from the past 20 years to determine the effects of intermittent fasting on chronic disease in adults through evaluation of biological markers pertaining to inflammation, oxidative stress, and the cardiovascular system. The dependent variables examined included heart rate, blood pressure, and cholesterol levels for cardiovascular risk; leptin and TNF-a for inflammatory risk; and F2-Isoprostanes and free radicals for oxidative stress biomarkers. The reviewed studies found that there was a decrease in resting heart rate, systolic and diastolic blood pressure, blood LDL and total cholesterol levels, inflammatory cells, like …