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Full-Text Articles in Medicine and Health Sciences
The Role Of Accessory Domain In Cpsa Function And Capsule Production In Group B Streptococcus, Gina Difederico
The Role Of Accessory Domain In Cpsa Function And Capsule Production In Group B Streptococcus, Gina Difederico
Honors College
Group B Streptococcus (GBS) can be found in the vaginal and genitourinary tract of females, as well as the genitourinary tract of males, where it behaves as a commensal organism. However, as an opportunistic pathogen, GBS has the capability to infect the immunocompromised, making it a major threat to neonates and fetuses. The pathogen can be passed from mother to baby either in utero or during birth. The capsule, which is a polysaccharide coating on the outside of the cell, is considered the most important virulence factor in GBS.Expression of capsule plays a role in evasion of the host immune …
Updates On The Diagnosis And Management Of Hepatocellular Carcinoma, Aimun Raees, Muhammad Kamran, Hasan Özkan, Wasim Jafri
Updates On The Diagnosis And Management Of Hepatocellular Carcinoma, Aimun Raees, Muhammad Kamran, Hasan Özkan, Wasim Jafri
Section of Gastroenterology
Introduction: Globally, the incidence, as well as mortality, related to hepatocellular carcinoma (HCC) is on the rise, owing to relatively few curative options. Underlying cirrhosis is the most common etiology leading to HCC, but risk factors of cirrhosis show great regional variability. Over the years, there has been a steady development in the diagnostic and therapeutic modalities of HCC, including the availability of a wide range of systemic chemotherapeutic agents. We aim to review the recent advancements in the diagnostic and therapeutic strategies for HCC.
Methodology: The literature search was done using databases PubMed, Cochrane, and Science Direct, and the …
A Species-Wide Genetic Atlas Of Antimicrobial Resistance In Clostridioides Difficile, Korakrit Imwattana, César Rodríguez, Thomas V. Riley, Daniel R. Knight
A Species-Wide Genetic Atlas Of Antimicrobial Resistance In Clostridioides Difficile, Korakrit Imwattana, César Rodríguez, Thomas V. Riley, Daniel R. Knight
Research outputs 2014 to 2021
Antimicrobial resistance (AMR) plays an important role in the pathogenesis and spread of Clostridioides difficile infection (CDI), the leading healthcare-related gastrointestinal infection in the world. An association between AMR and CDI outbreaks is well documented, however, data is limited to a few ‘epidemic’ strains in specific geographical regions. Here, through detailed analysis of 10330 publicly-available C. difficile genomes from strains isolated worldwide (spanning 270 multilocus sequence types (STs) across all known evolu-tionary clades), this study provides the first species-wide snapshot of AMR genomic epidemiology in C. difficile. Of the 10330 C. difficile genomes, 4532 (43.9%) in 89 STs across clades …