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Regulation Of Apoptosis During Environmental Skin Tumor Initiation, Bilal B. Hafeez, Eunmi Park, Kyung-Soo Chun, Yong-Yeon Cho, Dae Joon Kim
Regulation Of Apoptosis During Environmental Skin Tumor Initiation, Bilal B. Hafeez, Eunmi Park, Kyung-Soo Chun, Yong-Yeon Cho, Dae Joon Kim
School of Medicine Publications and Presentations
Skin cancer is more prevalent than any other cancer in the United States. Nonmelanoma skin cancers are the more common forms of skin cancer that affect individuals. The development of squamous cell carcinoma, the second most common type of skin cancer, can be stimulated by exposure of environmental carcinogens, such as chemical toxicants or UVB. It is developed by three distinct stages: initiation, promotion, and progression. During the initiation, the fate of DNA-damaged skin cells is determined by the homeostatic regulation of pro-apoptotic and antiapoptotic signaling pathways. The imbalance or disruption of either signaling will lead to the survival of …